What Causes Pediatric Cancer

  Within Solitarius:  My Main Goal has been to always supply the visitant with the best information that is on the world wide web. Regardless and in  the top tag Childhood Cancer  includes  links  for some of  the best  facilities in the United States.  Along with other links  where  you  can grab n’ go  the  information in a hurry?

     Pediatric  cancer  cases  are  much  different  from  adult  cancer cases, whereas  they  develop  much  faster than cancer in adults, and  for decades medical researchers have not been able to identify “why” around the globe. Recently  however,  researchers  at  the  Center  for  Childhood  Cancer  and Blood  Disease  at  the  Nationwide  Children’s Hospital  in  Columbus  Ohio have  finally  pin pointed  the  reason “why”  pediatric  cancer  progress  so quickly.

  The Key according to Dr. Changxian Shen, PhD., whom is senior research associate  at the center,  and  Dr.  Peter Houghton PhD.,  who  is  the  centers director.  Lies in the checkpoints  that  encourage cells  to  repair themselves before they replicate their DNA.  Many researchers believe cancer cells may flourish when these checkpoints  are  skipped  or  inhibited,  as the mutated cells survive and rapidly reproduce.

   Prior studies had shown that the DNA damage check point protein ATM,  was  ‘very low’  in most pediatric solid tumor cases. There are many different issues contributing  to this phenomenon,   first  and  foremost,  are  the  over  production  of  microRNAs  reducing  the  amount  of  ATM  that  is  created, which leads to cells circumventing  the damage check point  when this does happen. Cells that have mutated DNA  are able to reproduce  without going through the repair process that ATM is suppose to help SPARK.

    Indeed Dr. Houghton, also turns his attention to the way in which this discovery  can  assist  in  creating more effective treatment options.  These results help us to understand,  not only,  the early genesis of  some tumors, but also,  “why”  so many solid tumors are sensitive to drugs  and ionizing radiation that damage DNA.

    This also help explain  “why”  in children not cured by these treatments. resistance to therapy arises ~ the rapid rate of mutation due to suppression of  ATM.  Potentially  the  rate  of  mutations that lead  to drug  or  radiation resistance  could  be  slowed  by  targeting  the  mTOR  pathway  [ which is responsible  for  the over production  of  microRNAs ]. Like me…. you don’t have  to  fully understand this research,  however,  The Children’s Hospital in Columbus,  Ohio   would be a great starting point in your search  for the answer  for cancer.

     Also  Children’s Cancer Recovery Foundation  supports  families  via numerous programs  that are aimed  at helping parents.  Keep a roof  over their children’s  heads  despite  surmounting  medical  bills  and  providing gift’s to kids who are going through the stressful process of   fighting their   type of  cancer.  Ultimately,  the goal  of  the program  is to create the least stressful environment,  so kids  and  love ones  can  focus  their  energy  on healing  and overcoming the threat cancer poses.


The  St.  Baldrick’s  Foundation

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