Nothing Positive Comes from Negativity

Map based on the last Senate election in each state as of 2022. (Wikimedia)
By Lee Smith | March 30, 2023

Would a secession lead to another civil war?
Do You Speak American? Sea to Shining Sea . American Varieties | PBS
How many foreign dialects are in the united states – Search (bing.com)
North American Regional Dialects & Accents – Vivid Maps

It hardly comes as a surprise that so many are asking whether we should part ways
before the divide gets even worse. With the Civil War, America was split by region,
north and south. Today it’s worse—the country is divided not just politically but by
class, race, and sex, too.
Left and right, blue and red, have different values and thus dream differently for themselves and their families and hold competing ideals for the country they share.
It hardly comes as a surprise then that so many are asking whether we should part
ways before the divide gets even worse.

“We are very much a divided country,” says F.H. Buckley,
author of “American Secession: The Looming Threat of a National Breakup.”
“We don’t agree about basic things. In the past, I think we all agreed about ends,
about what we wanted of America, and we disagreed about how to get there.

But now we disagree about ends; we disagree about the basic nobility of the American Revolution, about the founders of a country, about a lot of basic beliefs that formerly all were held in common, the idea that marriage is a good thing, and so on.

And so, unsurprisingly, that’s led to people saying,
‘Do we really belong together in one country?’


Buckley is a foundation professor at George Mason University’s Scalia School of law, and
I spoke with him in a recent episode of “Over the Target.” He says he doesn’t necessarily support secession, though he believes that “there is nothing per se wrong or objectionable about the idea of secession. If you think secession is always and everywhere a bad thing, then I guess what you’re saying is that the American Revolution was a bad thing.”

Typically, however, the secession debate leads back not to America’s declaration of independence from the British crown, but rather to the southern states’ departure from the union a little less than a century later. The crisis came to a head under the presidency of James Buchanan, “usually reckoned for some reasons as the worst American president, or one of the worst,” says Buckley.

He says his book is partly an effort to rehabilitate Buchanan.
Faced with South Carolina’s decision to secede from the union, Buchanan believed
it was a mistake and illegal, but that finally there wasn’t much he could do about it.
As Buckley characterizes the thinking of the 15th U.S. president:
“What am I supposed to do? Am I supposed to call up the troops and invade you?
I don’t think I should do that. I’m not even sure if Congress has the right to do that.”

But Abraham Lincoln didn’t have those kinds of misgivings.
What Lincoln objected to, says Buckley, “was not slavery, but disunion.
Slavery as a cause came along later, after Antietam. But it wasn’t there in the
spring of 1861. … Lincoln himself said, ‘I also have no desire to interfere with
slavery.’ And moreover, he said, ‘I would approve a constitutional amendment
which guarantees the right of slavery in the states forever.’”

Lincoln’s decision to invade the south was based on a “very wrongheaded” “view of the Constitution,” says Buckley. “But I also think his decision was retroactively ratified by events, by the way in which the war turned out to be the cause for the abolition of slavery.” According to Buckley, one big question today is whether secession would lead to another civil war. “Would the president be more like Lincoln or more like Buchanan?”

Buckley believes that if secession were on the table,
“it would be done not by the assertion of unilateral right of independence, but as a prelude to a set of negotiations over the division of things, like the assets of the federal government or the division of the national debt. Then I think that what we’d end up with would be something like an Article V convention of the states, which is perfectly constitutional.”

Buckley, who holds Canadian as well as U.S. citizenship, says his understanding of secession is drawn from the recent history of our northern neighbors. “I lived through
a secession crisis in Quebec, where the separatists came within one percentage point of winning,” says Buckley. “It didn’t win, but the result was a series of discussions between the feds and the provinces about the allocation of powers.

And in the end, the provinces ended up with more responsibility.
One example would be the power of immigration. So right now, Canada admits immigrants, it’s a federal government, but Quebec has the right to veto immigrants who say they want to settle in Quebec.” Immigration is one of the crucial issues driving Red State voters into the national divorce camp.

By throwing open the borders, the federal government has exposed communities to felons and trafficking cartels. Between staying in a potentially deadly relationship and divorce, the latter is the rational choice. And with issues like election integrity, Second Amendment rights, school choice, and radical race and gender ideology taught in public schools, conservatives want to be liberated from the whims and self-serving dictates of Washington bureaucrats.

While state legislatures and governors are racking up wins on all these issues, it’s still
an uphill battle. “By virtue of the expansion of the federal government, particularly the spending power, many of the rules by which we live are really dictated by the feds,” says Buckley. Most of the Founding Fathers understood that, as Buckley’s book argues, bigger is worse and smaller is better. “The framers thought … that people are happier in small states, they’re better governed,” says Buckley.

“There’s a closer connection between the representatives and the representatives in small states, you can better reflect what people ordinarily want.” Nonetheless, he explains, one of the things that bothers even some proponents of national divorce “is the idea that we’d end up with walls” between states, says Buckley. “So if California seceded, there’d be this enormous wall between it and Nevada or Oregon. …

But that’s not what would happen,” he explains.

“We’d like to keep free trade between the states.
We’d like to keep free movement of goods and people. We wouldn’t want to have a passport to go to Oklahoma.” According to Buckley, we’d likely come up with something similar to what the Quebec government sought: sovereignty association. “What that would mean,” says Buckley, “is that Quebec would be sovereign with respect to some things and would share responsibility with the feds as to other things.”

In other words, it would be modeled after the U.S. Constitution,
or rather how Americans “thought about our constitution for at least 150 years.”
 Constitution 101: The Meaning and History of the Constitution
| Hillsdale College Online Courses And that’s where Buckley says the discussion
over secession ought to lead— “to a reconsideration of what federalism meant,
and a return to something close to what the Founders, in fact, wanted,
which is a kind of divided sovereignty.”

Views expressed in this article are the opinions of the author
and do not necessarily reflect the views of The Epoch Times.


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(2) Rhonda Dee Furin on Twitter states:
“It certainly seems to me that we are still a Nation At Risk. 
#Education should be at the top of Our Nation’s Agenda and
I will Make it Mine, Leaving No One Behind. Please Join me in Making Education Great, 
WINNING for the Kids, and Attaining that California Dream. #CA45 #MAGA https://t.co/VQlEqgS7Zu” / Twitter

I HAVE BEEN AN EDUCATOR ALL MY LIFE, BUT I AM SMART ENOUGH TO KNOW.
THAT I AM ALWAYS LEARNING AND I CAN’T POSSIBLY KNOW ALL THE ANSWERS. BUREAUCRATS IN WASHINGTON D.C. THINK THEY KNOW ALL THE ANSWERS BUT WE KNOW THAT THAT’S FAR FROM THE CASE.

COMMON CORE HAS BEEN A COMPLETE DISASTER FOR STUDENTS.
OUR EDUCATION SYSTEM SHOULD NOT BE ONE-SIZE-FITS-ALL BUT LOCALIZED AS MUCH AS POSSIBLE. SOME POSITIVE OPTIONS INCLUDE SCHOOL CHOICE PROGRAMS, MERIT-BASED TEACHER PAY, AND CHARTER SCHOOLS.

STOPPING SOCIALISM
Nancy Pelosi. Ihlan Omar. Alexandria Ocasio-Cortez. Bernie Sanders.
They’re all leading the charge to turn our country into a socialist dystopia.

When I am Governor,
I will swear an oath to protect and defend the Constitution against all enemies foreign and domestic. Unlike AOC and Omar, I will bear true faith and allegiance to this. It is the free market principles that I believe in, that our Founding Fathers believed in that allowed this country to flourish, that has brought more people out of poverty than any other government program, and will continue to do so if we allow it to.

BRINGING BACK THE CALIFORNIA DREAM
If California were a sovereign nation, it would rank as the world’s fifth-largest economy. However many Californians are being left behind. Housing has become unaffordable. Regulations on business have gotten out of control. US News and Reports ranked California as the worst quality of life in America. We can bring back the prosperity that great people like then-Governor Ronald Reagan lead us to. A good start would be to cut the red tape to bring jobs to our state, cut taxes so families can keep more in their pocket, and fix our crumbling infrastructure.

Bobby Knight once said, “you show me a screwed-up kid and I will show you
screwed up parents that raised them.” I think there is no doubt we’re a nation at risk.
We have so many blind, brainwashed, and low information people in our population we will remain so for perpetuity. People don’t want to be educated. Only 10% of Americans
get onto the internet to gain knowledge.

They don’t want to know. There are free empty libraries everywhere!
All most people want is to satisfy their desires and everyone else can fu€k off as far as they’re concerned. It’s the sad truth. How do you think we got here in the first place?

For some PR reason this is being blocked on my Campaign website. We may have to ask Hlpusd & their 5 PR they hired on Taxpayer money if they have any idea. I’m a retired teacher wanting to improve education by allowing for school choice. Make Education Great!

Rhonda before any of that can happen we need a culture change( shock)!
We have students who totally disrespect teachers’ authority. In fact teachers are held accountable when they discipline their unruly students! School Choice is a viable solution. Let’s see what we can get accomplished working with the right team, a winning team.

#KAG2020 Promises Made Promises Kept.
God Bless Rhonda. More conservatives are needed in California and to help rebuild our country, bringing back American values and traditions. I left California in 96 because of taxes, homelessness and unconstitutional gun laws. I pray that conservatives can reclaim the state! – Search (bing.com) 

We need to turn CALIFORNIA back RED!
Concentrate on voter registration!!! We don’t have so far to go!
Wouldn’t it be great to get conservative common-sense people like Rhonda in office, especially in CA where things are falling apart like never before because of decades of democratic misuse?

Our Motto: Fight, Fight, Fight!!!
Especially in Pelosi and Schiff districts, can’t take another term of those two. California definitely needs to turn red. What are you doing about the cheating 2 years ago that turned reliably red, Orange County blue? Also, cleaning up #SwampThingPelosi s district should be a priority as well. That AND getting rid of her. That’s LONG OVERDUE!!!

K-12 education in the U.S. is abysmal and I think it’s deliberate. It’s only when kids get to university (in most cases) that they learn anything accurate about the world. Education is where it all began. When we left it to the left, we lost education & gained indoctrination.

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These idiots have fucked this great country up so badly.
Started with the #douchebag on the left!
1st & 2nd worst President in history!

While kids fear for their lives at school, education will never improve.
List of mass shootings in the United States Doubled in 2012- Wikipedia
Lefties think that the only way…. is by firmer gun control can this happen.
Keeping guns out of the hands of the mentally disturbed. But it won’t happen.
Career politicians do not become multi-Millionaires on a government salary.
They become multi-millionaires by lying, cheating, stealing and with shady
dealings with other countries! Like the Bidens, Clintons. Pelosi…. Etc.

Where are the real investigations?
You can only vote if you are a registered Republican. http://sos.ca.gov
I strongly suggest checking your voter registration now and changing to Republican.
It’s more the Curriculum being taught than kids being left behind! These so-called highly qualified teachers are nothing more than highly qualified brainwashers! Not all teachers mind you; but a vast majority of them! Parents are spending $100000 for their children
to be indoctrinated in colleges.

Invest in their souls https://youtu.be/BLGfaGtkHkc
It ALL starts with EDUCATION-both at HOME and in public.
#CivilResponsibility
#CharterSchools
#ParochialSchools Jewish, Jesuit, etc.
#ResponsibleParents

Not until Tenure is abolished and teachers have to pass tests to continue teaching as well as having us go back to core classes that don’t include Political views in K-12 other than teaching what they are. No BLM, Antifa, no social movements. Balanced Education not indoctrination into Marxist philosophy. No more indoctrination

Leave no child behind and common core math was used to dumb down our kids to make less intelligent kids not FEEL bad. This was and still is an atrocity. We need to stop the emasculation and intentionally keep our kids ignorant.
This is done for power and control. #Schoolchoice

This is on http://opensecrets.org. 😧

We are in agreement when it comes to our educational system.
I have noticed over the last 10 years, how the district’s started closing schools and converting them into apartments. Which then forces more children to attend the few schools still operating. Now the classes are overcrowded. If #EDUCATION is your priority, does “Leaving No One Behind” include children of migrants? Even if the children are migrants themselves?

Rhonda Furin https://rhondafurin.com

Web Rhonda Furin Education Is My Top Priority It certainly seems to me that we are still a Nation at Risk. Education should be at the top of Our Nation’s Agenda, and I will Make it Mine, … 

The big idea of LCFF is that schools get money based on the needs of the students they are educating. Districts where there are many “higher need” students get more money to invest in those students. Here is how it works: 1. Base Funding: All districts receive a base grant for each student. 

LCFF was implemented which allowed for more flexibility and less accountability. Sadly, most districts have a spending problem that doesn’t reach the needs of the students it’s intended or designed to support. Education needs complete reform. A great starting point is to Teach your kids the constitution while you have a chance.

No child left behind IS a nation thing… and it was the first step to destroying public education for my generation and the ones to follow! NCLB brought RTI and “passed the buck to the next person” leaving kids to fall through the cracks! It was also a Benghazi thing. Stevens, Doherty, Smith, and Woods were all from California. 13 minutes VS 13 Hours.
Posted in Uncategorized | Leave a comment

The mRNA JAB

Tucker Carlson has recently created a video Quote Tweets / Twitter

In which he states that alarming research is coming out, regarding the Covid-19 vaccine effects. What the evidence from the medical journals that Tucker Carlson cites, shows, is that the vaccine destroys people’s immune systems, which is devastating to people who already have cancer and other health issues.

Red Voice Media has created a video explaining the Tucker Carlson video about new vaccine research that is coming out, and they discuss the media’s vehemence in this information coming out, and their many attempts to stifle any form of dissent. That video can be found here – Tucker Carlson: “Alarming Research About the Vaccine Coming Out” – Breanna Morello On Flyover Conservatives [VIDEO] (redvoicemedia.com)

In the Red Voice Media video, it is mentioned that Fox Corp took money from HHS and then censored negative vaccine coverage. HHS, of course, is the U.S. Dept. of Health and Human Services. So this shows that there was corruption going on, and that the news being presented at the time of the vaccine rollout, was anything but unbiased.
In this video, Red Voice Media play a clip of Tucker Carlson, talking about some of the negative side effects of the covid vaccines, which are – neurodegenerative disease, myocarditis, Bell’s palsy, liver disease, impaired adaptive immunity, impaired DNA damage response and tumorigenesis. Tucker Carlson then states,
“So it’s possible – in fact, it’s looking likely that the vaccines might suppress the immune system.” And it was this clip, that scared Dan Bongino so much, that he stated that taking the Covid vaccine was the biggest mistake of his life.

BREAKING: mRNA injections disable your natural immune system causing all kinds of disease along with heart problems and blood clots. Lancet study and other studies prove the mRNA injections are dangerous and deadly.

#SuddenAdultDeathSyndrome & #Myocarditis.

Wrong Arm Fauci – Search (bing.com)
It’s no vaccine. It’s a mRNA gene manipulator producing a spike protein that destroys
the body’s natural defenses. It’s dangerous and deadly, intended to thin the population.
Our leaders didn’t take it. They know it’s deadly. It is a weapon. Do not let your children get jabbed.

If you study the pathology of the mRNA vaccine it’s obvious it creates long term negative health consequences and almost certainly creates autoimmune disease in many people. This is an acceleration of disease, aging, cell death & shortening of HealthSpan.

Selected Adverse Events Reported after COVID-19 Vaccination | CDC
More than 672 million doses of COVID-19 vaccines were administered in the United States from December 14, 2020, through March 1, 2023. During this time, VAERS received 19,476 preliminary reports of death (0.0029%) among people who received a COVID-19 vaccine. CDC and FDA clinicians review reports of death to VAERS including death certificates, autopsy, and medical records. Continued monitoring has identified nine deaths causally associated with J&J/Janssen COVID-19 vaccination. CDC and FDA continue to review reports of death following COVID-19 vaccination and update information as it becomes available. It has been reported VAERS only had 10%
of the vaccines recorded on their website.

On January 22 the EU Medicines regulatory body
was warning about the effects of repeated vaccines.

They were right. 👇 Now mentioned in the Lancet.
COVID-19 pandemic on cruise ships – Wikipedia

When I did the sample size math of the cruise ships at the start of the pandemic.
Just slightly over 1 million American would have died given the US population is
330 million at the time. Virus Tracker – Search (bing.com)

See also the Cleveland Health Workers Vaccine study.
Dr. Paul Offit discusses concerns about COVID-19 vaccines and the immune system.
Do COVID-19 Vaccines Disrupt the Immune Response?

Full Story

The two messenger RNA, or mRNA, COVID-19 vaccines from Pfizer/BioNTech and Moderna work by priming the immune system so it can respond more quickly to a coronavirus infection. Large, randomized controlled trials and a substantial body of real-world data support the effectiveness and safety of the vaccines, which continue to provide strong protection against serious illness and death, especially after one or two booster doses.
Conservative television host Tucker Carlson, however, argued that the vaccines might be harming the immune system. On his July 21 broadcast on Fox News, he used dubious sources and cherry-picked and misrepresented data to incorrectly conclude that “it’s looking likely that the vaccine might suppress the immune system.” His comments were also shared on social media.
“Is it possible that the vaccine actually can hurt you, especially if you keep getting boosted? Can it weaken your immune system? Well, that looks possible,” he said, citing the journal Food and Chemical Toxicology, which he said “published the findings of several mRNA researchers, and we’re quoting, ‘In this paper, we present evidence that vaccination induces a profound impairment in type one interferon signaling, which has diverse adverse consequences to human health.’”  


Carlson went on to wonder why the press hadn’t covered the paper, which he quoted from again. “In fact, it’s looking likely that the vaccine might suppress the immune system,” he said. “This fact, the authors concluded, will ‘have a wide range of consequences, not the least of which include the reactivation of latent viral infections and the reduced ability to effectively combat future infections.’”

Carlson then falsely claimed that a study in the prestigious British journal the Lancet made “similar findings.” Virtually none of what Carlson said was accurate, however. It’s not “fact” that the vaccines suppress the immune system, nor is there any reliable evidence to suggest that it could be true.
The paper that Carlson cites, which was written by some individuals opposed to COVID-19 vaccination, misrepresents and distorts other scientists’ findings to make illogical and unfounded claims. The lead author of the Lancet paper similarly told us that his work, which Carlson misrepresented, “does not show any” of what Carlson alleged.

Unreliable Food and Chemical Toxicology Paper
Carlson’s primary evidence for the vaccines harming the immune system is a much-criticized Food and Chemical Toxicology paper written by several individuals known for being opposed to vaccination or for spreading health misinformation. 
Lead author Stephanie Seneff is a computer scientist at the Massachusetts Institute of Technology who has falsely claimed that vaccines cause autism and has pushed a theory linking the herbicide glyphosate to COVID-19, 
among other unfounded scientific views.
Senior author Dr. Peter McCullough is an internist who has repeatedly spread misinformation about COVID-19 treatments and the vaccines. Another author, Greg Nigh, practices naturopathy, a form of alternative medicine that has often embraced pseudoscientific methods. 

When the paper was first published in April, numerous critics condemned it, with some calling for it to be retracted. (That effort was denied. Notably, the paper appeared in the journal after the editor-in-chief put a call out for papers “on potential toxic effects of COVID-19 vaccines.”)
The paper, which does not present any original research, is a review coupled with an analysis of data from the Vaccine Adverse Event Reporting System, the United States’ early warning system to detect possible safety problems with vaccines. VAERS reports can be submitted by anyone, are not vetted for accuracy, nor do they mean that a reported symptom was necessarily caused by the vaccine; the data have often been mined to incorrectly claim vaccines are dangerous.

Some parts of the literature review are correct, but the conclusions the authors draw about immune function following vaccination are unfounded, experts told us — and the VAERS analysis is flawed, as Jeffrey S. Morris, a biostatistician at the University of Pennsylvania, has explained on Twitter and on his blog.
“This long review article presents many details about various biological pathways, but their links to mRNA vaccines are almost wholly speculative. In some cases, they link to other vaccines, old mRNA technology, or COVID-19 infection, but are not directly linked to mRNA vaccines,” Morris wrote.

“In fact, so much of their evidence is from papers on severe COVID-19 infections, not vaccination, much content in this article might be better suited to a paper pointing out potential downstream dangers of severe COVID infections rather than raising alarm about mRNA vaccination,” he added.
One of the paper’s core claims is that the mRNA COVID-19 vaccines suppress the innate immune system, specifically the type I interferon response. Interferons are antiviral proteins that help limit the spread of a viral infection, although they also can lead to harmful inflammation. This is the supposed basis the authors use — and Carlson cites — to claim that the vaccines would make it harder to respond to infections and increase the risk of cancer.

But experts who study the interferon response say that’s bogus.
“I am not aware of any report that demonstrates what [is] claimed in the review,” Ivan Zanoni, an immunologist at Boston Children’s Hospital who has studied the interferon response in patients infected with the coronavirus, told us in an email. 
It “doesn’t make any sense with what we know about the vaccine and how it works, and neither it makes sense to what we know about how the immune system works,” he added.
Elina Zúñiga, a molecular biologist at the University of California San Diego who studies interferon and has reviewed its role with COVID-19, agreed.

“The authors make some connections to speculate on a possibility, but there is no data or scientific evidence supporting the statement that interferon signaling is suppressed in vaccinated individuals,” she told us in a phone interview.
In fact, Zanoni said, available evidence contradicts the notion that vaccination reduces a person’s ability to mount an interferon response. One paper, he said, reported that people who had received one dose of the Pfizer/BioNTech vaccine prior to being hospitalized for COVID-19 had a better antiviral interferon response than those who were not vaccinated.

Another paper also argues against the idea, Zanoni said.
A lab at Rockefeller University discovered early in the pandemic that a subset of people who develop severe COVID-19 produce antibodies that block their own interferons. These antibodies prevent the interferons from helping fight the coronavirus early in infection, and likely explain the severe disease. The same lab has since found that the same applies to vaccinated people — and that individuals with the interferon autoantibodies are likely to be at higher risk of severe illness, even after vaccination.
If the vaccines were suppressing the interferon response, as the review proposes, vaccinated people with autoantibodies would not be at higher risk because interferons would already be suppressed, Zanoni said.
To make its claim that the vaccines suppress interferon, the Food and Chemical Toxicology review cites an unpublished study that found a much larger interferon response in certain immune cells from people with active coronavirus infections compared with those from people before and after vaccination. 

But an author of the study told us that’s an incorrect interpretation of the findings.
“We observed higher levels of interferon signaling in cells from patients with COVID-19 illness than in adults receiving the mRNA vaccines. The paper citing our work is misinterpreting the lack of inflammation to be the same as ‘active suppression,’” Sergei B. Koralov, the senior author of the study and an immunologist at the New York University Grossman School of Medicine, told us in an email. He added that his group “did not see anything in our data that implies active suppression.”

“We saw very low levels of inflammation in the immune cells following mRNA vaccine in contrast to the high levels that we saw with SARS-CoV-2 virus infection,” he said. “The main message of our manuscript is that even in the absence of inflammation found in the course of infection, vaccination elicits a robust and long-lasting immune response.”
Indeed, less inflammation in the context of a vaccine is part of the point — a vaccine is supposed to provide immunity without the harmful effects of infection.
“This is not surprising at all and there’s nothing wrong with that,” Zúñiga said of the lower interferon response following vaccination. She also iterated that the finding in no way suggested that the vaccines would diminish the immune system’s interferon response to other pathogens.

Misrepresented Lancet Study
Risk of infection, hospitalization, and death up to 9 months after a second dose of
COVID-19 vaccine: a retrospective, total population cohort study in Sweden – The Lancet
In an effort to lend credibility to his argument, Carlson also claimed that a Lancet publication supported the conclusions of the Food and Chemical Toxicology paper.

The Lancet paper recommended third dose COVID-19 vaccine boosters.
Carlson cited a comment a Japanese physician, Dr. Kenji Yamamoto, published in a different journal, which claimed the Lancet paper “showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the unvaccinated individuals.”
After suggesting that the Lancet paper hid “a major finding,” Carlson pointed to one piece of data in table 3 of the paper for viewers to check themselves. “Among people around the age of 80 who have been double vaccinated — that would include people like Joe Biden — the per capita rate of medical incidences, including hospitalizations or death, is nearly twice as high as the rate of serious incidence for the unvaccinated,” he said.
Carlson added that the Lancet paper “also includes a chart showing negative vaccine efficacy for all ages after eight months for all participants in the study.”

Carlson, however, is distorting cherry-picked data from the paper.
“The paper we have published [does] not show any of the claims” Carlson made, lead author Dr. Peter Nordström told us in an email, because they were not statistically significant. The findings that are statistically significant and the conclusions of the paper are “presented in the summary of the paper,” he added.
The paper, which was published in February, used nationwide registers in Sweden to evaluate COVID-19 vaccine effectiveness against infection, hospitalization and death for up to nine months after full vaccination, from December 2020 to October 2021. It found that vaccine effectiveness against infection of any severity waned over time, with some differences by vaccine type (Sweden used the two mRNA vaccines and the AstraZeneca vaccine). There was less waning of vaccine protection against severe COVID-19 —
but still some after four months, which the authors said strengthened the rationale
for implementing booster doses.

Nicholas Jewell, chair of biostatistics and epidemiology at the London School of Hygiene and Tropical Medicine, told us Carlson’s interpretation of table 3 was “hopelessly wrong and misleading.” 
It’s true that for the 80 years and above age group after about six or more months, vaccinated people had nearly twice the incidence of coronavirus infection of any severity as the unvaccinated (1.8 vs. 1.0 per 100,000 person days). However, that’s the raw data — and again, it’s for infection of any severity, not just hospitalizations or deaths, as Carlson suggested.
When the data are adjusted for age and time elapsed since vaccination, Jewell noted in an email, “the data shows the vaccinated individuals in this group to be very slightly better off than the unvaccinated” (a vaccine effectiveness of 4%, rising to 5% with additional adjustments).

The vaccine effectiveness numbers are not statistically significant, so they’re very uncertain. In reality, Jewell said, we “simply don’t know what the effectiveness is for this age group on this time scale since vaccination,” although the evidence “still points to vaccinated individuals being protected from the negative outcome.”
Not only is it inaccurate to conclude from this data that the vaccinated are at higher risk than the unvaccinated, but Carlson also cherry-picked the data. As Jewell noted, the unadjusted data he highlighted is the only such data in the table that shows a higher raw infection frequency among the vaccinated.
“In the other 36 rows,” he said, which show vaccine effectiveness estimates at different times since vaccination for various demographic groups, the vaccinated are the same or better off, sometimes “much better off and definitively so!”

Carlson’s interpretation of figure 2 of the paper, which plots the decline of vaccine effectiveness against infection of any severity over time, is also “completely wrong,” Jewell said. That’s because there is considerable uncertainty in the data, shown by the shaded area, which always includes zero.
“These shaded areas tell us that we have no evidence for effectiveness after 8 months,” Jewell said. “What the figure similarly does not show is that there is evidence of negative vaccine efficacy.”
As for the Japanese physician who claimed the Lancet data “showed that immune function among vaccinated individuals 8 months after the administration of two doses of COVID-19 vaccine was lower than that among the unvaccinated individuals,” Jewell said he found nothing to support that in the Lancet paper, as it also appears to be an erroneous interpretation of figure 2.

Yamamoto’s comment shows a misunderstanding of the figure, and it also incorrectly generalizes a specific and expected decline in immunity to the coronavirus over time following vaccination with a general decline in immunity to all things.
There is no evidence of that in the Lancet paper, nor anywhere else.

Editor’s note: SciCheck’s COVID-19/Vaccination Project is made possible by a grant from the Robert Wood Johnson Foundation. The foundation has no control over our editorial decisions, and the views expressed in our articles do not necessarily reflect the views of the foundation. The goal of the project is to increase exposure to accurate information about COVID-19 and vaccines, while decreasing the impact of misinformation.

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F.Y.I., I did not take the jab and survived being gravely ill from the virus.
I agree with Tucker: the vaccine compound the health concern of the virus.

Sources
The immune system and immunization.”
Immunization Advisory Centre, the University of Auckland. Accessed 29 Jul 2022.
Schwarcz, Joe. “Glyphosate and COVID-19: Dr. Stephanie Seneff Strikes (Out) Again.” McGill Office for Science and Society. 1 May 2020.
de Block Golding, Daniella. “Covid-19 vaccines are not associated with developing neurodegenerative diseases.” Full Fact. 24 Jan 2022.
Gorski, David. “Scientific review articles as anti vaccine disinformation.”
Science-Based Medicine. 25 Apr 2022.
McDonald, Jessica. “Vaccines Remain Largely Effective Against Delta Variant, Counter to Claims From Fox News Guest.” FactCheck.org. 30 Jul 2021.
‘Natural’ doctors face skepticism from practitioners of conventional medicine.”
Consumer Reports. 9 Apr 2018.
Thielking, Megan. “‘Essentially witchcraft’: A former naturopath takes on her colleagues.” STAT. 20 Oct 2016.
Bergstrom, Carl T. (@CT_Bergstrom). “There’s a new paper out making unsubstantiated claims about vaccine safety or the lack thereof. @jsm2334 has tackled the substance of the paper in exhaustive detail in the thread below; I simply want to comment on what should be an obvious red flag before you even start reading.” Twitter. 21 Apr 2022.
Schneider, Leonid. “Elsevier pandemic profiteering, again.” For Better Science. 20 Apr 2022.
Morris, Jeffrey S. (@jsm2334). “Does a recently published paper by Peter McCullough and colleagues really “establish a mechanistic framework” for mRNA vaccine harm? https://sciencedirect.com/science/article/pii/S027869152200206X…
This thread will explore that question.@AshishKJha46 @lpachter @nataliexdean @MonicaGandhi9 @CT_Bergstrom @BallouxFrancois.” Twitter. 21 Apr 2022.
Barriere, Jérôme (@barriere_dr). “Dear friends Let me tell you about a recent editorial experience hard to believe: the editorial scandal of the anti-VAX article by Seneff et al. published in Food and Toxical Toxicology (IF 6) (@elsevier), refused to be retracted by EIC JL Domingo https://sciencedirect.com/science/article/pii/S027869152200206X.” Twitter. 13 Jun 2022.
Barriere, Jérôme et al. “Reply to “Innate immune suppression by SARS-CoV-2 mRNA vaccinations: The role of G-quadruplexes, exosomes, and MicroRNAs”: Important concerns on the validity of this article.” OSF Preprint.
Domingo, José L. “Call for Papers on potential toxic effects of COVID-19 vaccines.”
Food and Chemical Toxicology. 3 Jan 2022.
McDonald, Jessica. “Increase in COVID-19 VAERS Reports Due To Reporting Requirements, Intense Scrutiny of Widely Given Vaccines.” FactCheck.org. 22 Dec 2021.
Morris, Jeffrey. “Does McCullough’s paper really “establish a mechanistic framework” for mRNA vaccine harm?” Covid-19 Data Science. Blog post. Updated 23 Apr 2022.
Chiale, Carolina et al. “Interferon induction, evasion, and paradoxical roles during SARS-CoV-2 infection.” Immunological Reviews. 1 Jul 2022.
McNab, Finlay et al. “Type I interferons in infectious disease.”
Nature Reviews Immunology. 23 Jan 2015.
Zanoni, Ivan. Associate professor of pediatrics in the field of immunology, Boston Children’s Hospital. Email to FactCheck.org. 26 Jul 2022. 
Zúñiga, Elina. Professor of molecular biology, University of California San Diego.
Phone interview with FactCheck.org. 27 Jul 2022.
Knabl, Ludwig et al. “BNT162b2 vaccination enhances interferon-JAK-STAT-regulated antiviral programs in COVID-19 patients infected with the SARS-CoV-2 Beta variant.” Communications Medicine. 22 Feb 2022.
Bastard, Paul et al. “Vaccine breakthrough hypoxemic COVID-19 pneumonia in patients with auto-Abs neutralizing type I IFNs.” Science Immunology. 14 Jun 2022.
Bastard, Paul et al. “Autoantibodies against type I IFNs in patients with life-threatening COVID-19.” Science. 24 Sep 2020.
Ivanova, Ellie N. et al. “SARS-CoV-2 mRNA vaccine elicits a potent adaptive immune response in the absence of IFN-mediated inflammation observed in COVID-19.”
medRxiv. 23 Aug 2021.
Koralov, Sergei B. Associate professor, department of pathology,
NYU Grossman School of Medicine. Email to FactCheck.org. 27 Jul 2022. 
Nordström, Peter et al. “Risk of infection, hospitalisation, and death up to 9 months after a second dose of COVID-19 vaccine: a retrospective, total population cohort study in Sweden. The Lancet. 4 Feb 2022.
Nordström, Peter. Professor and attending physician, Umeå University.
Email to FactCheck.org. 27 Jul 2022.
Jewell, Nicholas. Chair of biostatistics and epidemiology, London School of Hygiene and Tropical Medicine. Emails to FactCheck.org. 27 and 28 Jul 2022.

Categories Factcheck Posts
 Scicheck
Location International
Issue Coronavirus
 COVID-19
 COVID-19 Vaccination
People Tucker Carlson
Misconceptions Distortions Of Science
 Vaccination Immunity
Posted in Uncategorized | Leave a comment

Best and Worst States

By NEIRIN GRAY DESAI FOR DAILYMAIL.COM
PUBLISHED: 16:17 EDT, 2 April 2023 | UPDATED: 16:53 EDT, 2 April 2023

REVEALED: The ten best and worst states in the U.S. if you want to live a long
and healthy life… and California didn’t even make the top five.
States like Hawaii, Minnesota, Vermont, Washington and New Hampshire had both healthy lifestyles and higher life expectancies, according to a new study by biomedical research and longevity society.

There is a strong correlation between lifestyle and life expectancy, study finds
Federal data on overall healthiness was compared with life expectancy by state
West Virginia, Mississippi, Alabama ranked Louisiana ranked last for both.

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Pictured is the famous Waikiki Beach in Honolulu

Hawaii was the only state with a life expectancy greater than 80 and was the fourth most healthy, according to federal data. Hawaii was rated the highest overall for those seeking
a healthy lifestyle and high life expectancy, followed by Minnesota, Vermont, Washington and New Hampshire.

Similarly, states with the lowest life expectancy tended to be the states with the least healthy lifestyles and were mainly in the southeast. West Virginia was ranked last overall, followed by Mississippi, Alabama, Louisiana and Kentucky. Notably, California did not even make the top five most healthy states, ranking 14 for healthy lifestyle, but it tied fifth with Massachusetts and New Hampshire for life expectancy.

‘Life expectancy’ is determined by a number of factors, including healthcare and murder rates, but a study carried out by biomedical research and longevity society, Life Extension, suggests general healthiness plays a major role too.

Related video: 9 Best Places to Live in the U S for a Healthy Lifestyle (Travel + Leisure).

These Are the Best Exercises to Burn Belly Fat As Fast As Possible (msn.com)

10 common foods that are difficult to digest (msn.com)  

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The overall healthy lifestyle ranking was informed by federal data measuring the following:

Amounts of exercise, proximity to parks and schools, fruit and vegetable consumption, hours of sleep, body weight, number of single people, anxiety levels and state expenditure on outdoor recreation. Although it found there was a strong correlation between healthy lifestyles and life expectancy, there were also some exceptions.

Outliers include DC and Montana, where life expectancies were low despite the fact they appeared to have healthy lifestyles. In general, DC’s low life expectancy was explained by racial disparities and a high incidence of heart disease, cancer and homicide, according
to the Life Extension study. DC is also a city and not a state, so it often appears off when considering state-wide data.

This 197-Year-Old Man’s Longevity Secret Makes Your Cells 4 TIMES Younger.
Youth Switch (longevityactivation.com)

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States in which more money was directed towards outdoor recreational
activities tended to have higher life expectancies © Provided by Daily Mail

States with worst life expectancy
Mississippi: 71 years and 11 months
West Virginia: 72 years and 10 months
Louisiana: 73 years and a month
Alabama: 73 years and two months
Kentucky: 73 years and six months
Tennessee, Arkansas: 73 years and 10 months
Oklahoma: 74 years and a month
New Mexico: 74 years and six months
South Carolina: 74 years and 10 months
Indiana: 75 years

States with best life expectancy 
Hawaii: 80 years, and eight months
Washington: 79 years and two months
Minnesota: 79 years and a month
California, Massachusetts and New Hampshire: 79 years
Oregon, Vermont: 78 years and nine months
Utah: 78 years and seven months
Connecticut, Idaho: 78 years and five months
Colorado: 78 years and four months
Rhode Island: 78 years and three months
Maine: 77 years and nine months 

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The above graph shows life expectancy in the US by year, according to the Centers for Disease Control and Prevention. Rates plateaued in the mid-2010s but dropped off after the Covid pandemic – which led to many people dying prematurely. Experts say the surging opioid epidemic is also to blame for the fall
On the other hand, Connecticut and New York had higher life expectancies given the relatively unhealthy lifestyles of their inhabitants. 
Montana, Alaska and North Carolina had generally good health habits but only average life expectancies.
Lower life expectancy in poorer states has also been blamed on worse healthcare systems and more residents without health insurance.
However, those states also have higher rates of chronic diseases – such as obesity – raising the risk of a myriad of other conditions such as heart disease and high blood pressure later in life.
America’s life expectancy was 79 years and a month in 2020, according to data from the National Vital Statistics System.
Last year marked the second year on record that it had declined, and an almost two-year downturn from 2019. Every single state registered a decline in life expectancy between 2019 and 2020.
New York – which was hit especially badly during the first year of Covid – saw the largest decline, falling almost three years.

State health
BEST STATES FOR THE HEALTHIEST AND LONGEST LIVES – Search (bing.com)

Read more

Q. How many hours of sleep do I need by age?

doctorIconRound
Dr. Howard E. LeWine
M.D. Chief Medical Editor,
Harvard Health Publishing · 40 years of experience · Flag image of USA USA
As adults age, many find they need less sleep. But at any age, the right amount of sleep for you is variable. In general, experts recommend between six and nine hours per night. Sleep quality is just as important as the number of sleep hours.

doctorIconRound
Dr. Marcella Abunahman Pereira
Specialization in Clinical Cardiology · 12 years of experience · Flag image of Brazil Brazil
A newborn (0–3 months) needs 14–17 hours of sleep. An infant (4–12 months) needs 12–16 hours per 24 hours. A toddler (1–2 years) needs 11–14 hours per 24 hours. Preschool
(3 – 5 years) needs 10–13 hours per 24 hours. A school age (6–12 years) needs 9–12 hours per 24 hours. A teenager (13–18 years) needs 8–10 hours per 24 hours.
An adult (over 18 years) needs 7 – 9 hours per night.

doctorIconRound
Dr. Marcelle Freire
Doctor of Medicine · 3 years of experience · Flag image of Brazil Brazil
The amount of sleep needed varies. Some may have a greater need, others less
and can be seen by the amount of energy during the day. But on average, according
to the CDC (USA), the amount of sleep per age is: Newborn (0–3 months) – 14–17
hours/day Baby (4–12 months) – 12–16 hours/day (including naps).
Child (1–2 years) – 11–14 hours/day (including naps) Preschool (3–5 years) –
10–13 hours/day (including naps) School age (6–12 years) – 9–12 hours/day
Teenager (13–18 years) – 8–10 hours for 24 hours/day Adult (18–60 years) –
7 or more hours/day

Answers from other regions
Disclaimer:  Medical advice varies across regions. Advice from professionals
outside your region should be used at your own discretion. Or you should –
contact a local health professional.

SOURCE Sleep: Ask Health Professionals (msn.com)

Posted in Uncategorized | Leave a comment

The Evil Empire Must Not WIN

From CPAC 2023: Why We Need a New Federal State of China | The Gateway Pundit
by Kelly John Walker

Anyone who attended February’s CPAC event in Washington, D.C. could tell you that one exhibitor was impossible to ignore: The New Federal State of China (NFSC). Who are these people, and what do they seek to achieve?

NFSC is perhaps America’s greatest anti-CCP ally
in the Cold War against the CCP
On June 4, 2020, the New Federal State of China launched in New York City with one overarching goal: “Take down the CCP (Chinese Communist Party).” Yet, these freedom-seeking people encountered an America that has been infiltrated by the evil communist regime they came here to escape. America is not the beacon of freedom it once was…but a base of 500 million supporters desperately want to see our country resume the mantle of World Leader and Champion of Liberty. As American lawmakers are increasingly realizing, America cannot do that until it decouples from the CCP.
Tough times make tough people, and the New Federal State of China is made up of graduates from the school of hard knocks. Some have been arrested, others have been tortured; many worry that the CCP is targeting family members back in China in attempts to intimidate them. One young man shared that his mother sits in a CCP prison back in China. Nevertheless, the NFSC’s people are brave enough to face down a regime arguably worse than any of the 20th-Century’s most insidious regimes, including Nazi Germany,
the Soviet Union, and the Japanese Empire.

“Take down the CCP” needs to be a defining slogan of our times.
The New Federal State of China is perhaps America’s greatest anti-CCP ally in the Cold War against the CCP, and their rallying cry of “take down the CCP” needs to be a defining slogan of our times. The group brought their energy, enthusiasm, and tech savvy to CPAC,
At three booths buzzing with non-stop activity, reportedly doing about 90 interviews per day, livestreamed to NFSC Speaks @ https://gettr.com/user/NFSCSpeaks.
These NFCS efforts are a key component of the Information War against the CCP.
Guests included congressmen, heads of state, NGO leaders, independent news organizations, journalists, prominent dissidents from all over the world, and more.

“You can count on Congress.
To take back America from the CCP’s manipulation and weaponization of U.S. federal government agencies.” -Texas Congressman Keith Self and Pennsylvania Representative Scott Perry discussed his bill, which would “label the Communist party of China a transnational criminal organization.”
He also pointed out the importance of separating the CCP from the Chinese people, who want to be free. “The Communist Party is not the friend of the United States of America,” he added.
Representative Keith Self shared his conviction that “you can count on Congress to take back America from the CCP’s manipulation and weaponization of U.S. federal government agencies. I think we will do that through the select committee on the CCP. We’ve got to find the facts, we’ve got to lay out the case, and then we’ve got to move forward!”

My Pillow Founder, Mike Lindell said during his interview that he will share NFSC’s call for an investigation into the CCP’s lawsuits against Mr. Miles Guo using America’s top law firms and proxies within the DOJ and FBI: “I’ll take what I’m hearing from you —
I’ll get it before…Jim Jordan and Kevin McCarthy…we’re behind everything you’re doing.”
“We’re not going to deny any righteous people that are speaking the truth like the NFSC,” said Washington Times Holdings Chairman, Michael Jenkins. “We’re happy to meet your leader and founder to discuss what are the facts, and I’m sure you’ll help enlighten the public!”
Newsmax host Grant Stinchfield won’t be on the air for the rest of the week
after a segment in which he said Israel is the “home country” of Jewish Americans.
Stinchfield’s comments came on Tuesday night when he criticized Sloe Joe Biden
for being unsupportive of Israel amid escalating violence between their military
and Hamas militants. Israel Defense Forces have also bombed residential buildings
and attacked Palestinian protesters in Gaza.

Newsmax host off air after calling Israel the ‘home country’ of Jewish Americans.

Grant Stinchfield Calls for Abolition of Four Government Agencies (mediaite.com)

JOIN THE STINCHFIELD TONIGHT SHOW 3-9-23 – One News Page VIDEO


While in D.C., NFSC representatives visited a D.C. studio for a live interview with Grant Stinchfield on Real America’s Voice. “The CCP is so scared right now,” said NFSC co-host, Prince Li after the interview. “Grant Stinchfield is amplifying our voice to expose their corruption to the world!”  Stinchfield with Grant Stinchfield on Apple Podcasts

The weapons of NFCS’s warfare are not rifles and grenades, but information.
In the war against the Chinese communist regime, NFSC is the modern-day equivalent
of the French Resistance that opposed Nazi aggression and the occupation of Europe.
With over 500 million followers, NFSC operates all over the world, including in China.
Some are even providing intelligence from within the government and military.
Unlike the freedom fighters of the past, however, the weapons of NFCS’s warfare
are not rifles and grenades, but information.
China took an early lead over the U.S. in the information and political warfare arenas.
If were to avoid a “hot war” with China, the U.S. must take back control of the narrative, win back hearts and minds, and—perhaps most importantly—heal the division the CCP has purposely exacerbated within our society and between our political parties.

We cannot free China until we first free America.
The NFSC organization is young and filled with optimism and
energy to take down the CCP, but their momentum isn’t just about their own struggles.
As NFSC representatives will tell you, we cannot free China until we first free America.
The testimonies and information these people have to share are key to restoring the greatness and independence of the People of the U.S. and the governance we all deserve.
As the Chinese Whistleblowers who escaped the oppressive regime back in China can attest, if communism wins, we all lose.
Kelly John Walker is an American statesman, writer, branding professional, and entrepreneur. He is the founder of FreedomTalk, host of FreedomTalk TV, and a freelance writer.

Yvette Wang and Miles Guo have sacrificed so much to #takedowntheccp . The deeply infiltrated DOJ, FBI and SEC will have consequences colluding with Communist China. But before that, they need to be released asap. Absolutely terrific news, since the seventh son Mr Guo and the families.
Have been organizing and fighting For freedom and liberty from the Evil CCP for some time now. DOJ, SEC, FBI, CDC, many legislators from various states, and many congressmen, are controlled by the Chinese communist party.
MILES GUO TODAY! TRUMP TOMORROW! The United States is on the verge of life and death, and no American has any way out. Now is the revolutionary moment to liberate the United States from the rule of the Chinese communist party!

FREE MILES GUO! FREE United States!
#milesguo #trump #freedom #revolution #freemilesguo #nfsc #nfsctv
https://www.instagram.com/p/CqgLbNgpgkc/?… #freemilesguo #freeyvettewang

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ISO 2023 Digital Currency – Search (bing.com)

BECOMING VENEZUELA: China Deal May COLLAPSE The US Dollar – YouTube
What’s on our financial horizon WILL impact your life…especially if America falls just like Venezuela did, which is a possibility, Glenn says. In this clip, he explains how new deals China currently is brokering with other nations — like Brazil, for example — means we’re facing something we’ve never experienced before: A collapse of the U.S. dollar. ‘Make no mistake,’ Glenn says. ‘If you want to be prepared, prepare yourself like people should have [done] in Venezuela.’ Plus, the Fed’s new Fed Now program — which could lead to a Central Bank Digital Currency (CDBC), will only make our chance of financial freedom even worse… Oh SH*T, the U.S. dollar is in real trouble | Morris Invest – YouTube

Anyone denouncing communism is considered a criminal by the WEF-controlled DOJ.
We don’t do anything at CPAC until we get our country back. 100M America dissent Biden & China’s maneuvers in America. Stop talking to Leftists, they are the minority and going down fast! China, Iran, and Russia don’t allow Trans, Drag Queens, Homosexuality, they don’t have trans men playing on girl teams.
Men and women have biblical values and children grow up with a mom and dad.
They have borders, no cartels, no fentanyl, (it’s not fun witnessing someone die 0f it)
and children are not trafficked. It seems like South America, North America, Europe,
Africa & Australia are getting the SLEAZE MAKEOVER from Claus & his oligarchs!

Image result for It’s time we change this NONSENSE!

It’s time we change this NONSENSE! – Search (bing.com)
Right like this would work. When all China has to do. It gives money, money in
payoff and kickbacks to Congress and Senate. To stop this group. Never going to happen. Our politicians in Washington are bought and paid for by China. Once the Communist’s get in, only violence will get them out. They are like cockroaches. The number one enemy of the CCP, Mr. Miles Guo knows the CCP best! Phoenix (Instrumental) – Bing video

The people who are from NFSC are freedom-loving Chinese people. We want a peaceful world without the Chinese Communist Party. Only by following Miles and the New Federal State of China to eliminate the CCP, the most evil regime in history, also the root cause of all global disasters, will WE THE PEOPLE have a future!

Thanks @gatewaypundit and thanks @CPAC to help us to voice out the evilness of the CCP. The New Federal State of China Led by Mr. Miles Guo, warned the whole world the CCP waged a bio war with the CCP Virus/Covid-19 against the whole world, but we were banned and censored by both social media and corporate media, or else more lives should have been saved with the correct information and early treatment.
The NFSC will be SURELY America’s greatest anti-CCP ally in the Cold War against the CCP. We love peace and freedom, and we will keep fighting to take down the communist regime and free all Chinese Laobaixing. #nfscspeaks #freeamerica #freemilesguo

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Miles Guo images – Bing images

Most Americans don’t understand why taking down the Chinese communist party terrorists is so important: America has gradually fallen into a police state like China,
under the CCP influence. No one is safe under the CCP. NFSC represents the good of Chinese Laobaixing. It’s the one all democratic countries can trust now.

The Chinese took to the streets protesting their lockdowns.
I guess no one in MAGA told them they must not protest because some radicals among them would commit acts of violence and play into the Communist Party’s hands. Or is it that everyone else in the world has the BALLS to protest injustice and only MAGA cowers at home telling themselves they’ll vote the FASMUNIST COUP out of power in America! Americans are too afraid of the FASMUNISTS to get out in the streets and protest.
But the Chinese didn’t let fear of BRUTAL COMMUNISTS stop them!

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Freedom isn’t Free. THEY deserve to be FREE!

Join us. Join the Whistleblower movement and NFSC to take down the CCP. It was the CCP who colluded with the traitors of the US to unleash the virus and mandated vaccines.
CCP is truly the origin of evil and all disasters. And, FREE MILES GUO, the biggest enemy of the CCP means he’s the best friend of Americans and the rest of the world. (edited)
NFSC is perhaps America’s greatest anti-CCP ally in the Cold War against the CCP!

CCP ≠ China. CCP ≠ Chinese. We are peace and freedom loving Chinese
from the New Federal State of China who strive to take down the CCP regime.

11/3/2020 AND 1/6/2021
These are the dates that The United States of America fell to The CCP.
Is it any wonder they don’t want “to look backward “?

新中国联邦人是灭共者,就是美国在冷战中对中共最大的反共盟友

Translated: The people of the New Federal State of China are the destroyers of the Communist Party, and they are the largest anti-communist ally of the United States against the CCP in the Cold War!!!

Biden & Marxist democrats have systematically ignored & intentionally slandered the founding fathers who wrote the constitution in order to undermine the rule of law into their political favor. 🙁 OBAMA = One Big Ass Mistake America. 🙁

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Alyssa Milano, Ivanka Trump, Jimmy Fallon, Kyle Rittenhouse, Ron DeSantis and more 
react to Donald Trump’s indictment in Stormy Daniels hush-money scandal (msn.com)

Stormy Daniels Weighs In On Donald Trump’s Indictment, Admits She’s ‘Scared’ For Her Safety.

‘SNL’ spoofs Trump indictment with music shoutouts to Taylor Swift, Alanis Morissette, Ice Spice.

Amazon.com: The Earth Transformed: An Untold History eBook: Frankopan, Peter: Kindle Store

Prayer That Changes Everything: 5 Principles to Activate Your Faith: Mary Colbert: Christianbook.com

Kaitlan Collins Visibly Stunned When Trump Attorney Throws OTHER Trump Attorney Under Bus In CNN Interview (msn.com)

‘Let Me Finish Now, Shipmate!’ Biden Spot John Kirby Goes NAVAL on Interrupting Reporter at Briefing (msn.com)

Where’s the ‘Forgotten Woman’ in Trump’s Hush Money Scandal? | Watch (msn.com)

Posted in Uncategorized | Leave a comment

Thought Provoking

Never forget Evelyn Dieckhaus 💔

Since Slow Joe was just there to eat Chocolate Chip Ice Cream.

President Joe Biden opened up a speech Monday to celebrate Women’s History…

Month by ranting about his love of ice cream. 

Biden was hosting an event at the White House to recognize the U.S. Small Business Administration Women’s Business Summit, announcing additional resources to help women small business owners and expanding the number of Women Business Centers networks.

The transcript reads: “Thank you. My name is Joe Biden. (Laughter.) I’m Dr. Jill Biden‘s husband. (Laughter.) And I eat Jeni’s Ice Cream, chocolate chip. (Laughter.) I came down because I heard there was chocolate chip ice cream. (Laughter.)”

Shortly after addressing others in the audience, including some children in attendance, the president went on to talk about the school shooting in Nashville.

President Joe Biden Accidentally Calls Mississippi Town Rolling Fork

instead ‘Rolling Stone’ In Latest Awkward Mix-Up (msn.com)

“Before I begin to speak, and the reason I spent a little time on the kids, I — I just want to speak very briefly about the school shooting in Nashville, Tennessee,” the president said. Since it was only a passing moment in Biden’s Day.  I thought I would exhibit proper condolence to family & friends of the victim of Covenant Grade School in Nashville Tennessee.

Yesterday was meant to be a day that 9-year-old Evelyn Dieckhaus was going to be singing Louis Armstrong’s “What a Wonderful World” in a play about jazz at her school. The Wonderful World she was going to sing about doesn’t exist. Because sadly, her life was taken away by the Trans Shooter. Never forget Evelyn Dieckhaus Love For Life!!!

Sarah McLachlan – I Will Remember You (Live)💓

A few days ago, was #TransDayOfVisibility where we saw Trans activists use violence, anger and hatred to push their ideology. They had no regard or thought for little Evelyn who should have been in her school jazz play. Instead, her life was cut short because of Radical Trans Ideology. And yes. LGBQ+ is an unfortunate curse by GOD, because of Sin. Sinful fleshly desires. God gave them over to these. Not sinning is Not giving into these desires. And asking the Lord for help staying strong and uncorrupted. But, there is still sin on both sides.

𝗧𝗵𝗲𝘀𝗲 𝗹𝗶𝘃𝗲𝘀 𝗺𝗮𝘁𝘁𝗲𝗿𝗲𝗱 #NeverForget as Biden celebrates #TransDayOfVisibility#TransgenderDayofVisibility
The unimaginable horror from the reports from affected families leave my heart broken. Whatever the motive for this heinous act, it is up for interpretation…We may never know, but what we do know for a fact, six innocent lives were eliminated.
Moment of silence 🤐 for the victims 🙏

God knows my/our hearts are broken 💔💫🙏

Can you imagine this angel’s 😇 family & friends?!

Isaiah 59:1-21 KJV

King James Version 59 Behold, the Lord’s hand is not shortened, that it cannot save; neither his ear heavy, that it cannot hear: Read full chapter Isaiah 59:1 Behold, the Lord’s hand is not shortened, that it cannot save; neither his ear heavy, that it cannot hear: [2] But your iniquities have separated between you and your God, and your sins have hid his face from you, that he will not hear. [3] For your hands are defiled with blood, and your fingers with iniquity; your lips have spoken lies, your tongue hath muttered perverseness. [4]
None calleth for justice, nor any pleadeth for truth: they trust in vanity, and speak lies; they conceive mischief, and bring forth iniquity. [5] They hatch cockatrice’ eggs, and weave the spider’s web: he that eateth of their eggs dieth, and that which is crushed breaketh out into a viper. [6] Their webs shall not become garments, neither shall they cover themselves with their works: their works are works of iniquity, and the act of violence is in their hands. [7] Their feet run to evil, and they make haste to shed innocent blood: their thoughts are thoughts of iniquity; wasting and destruction are in their paths. [8]
The way of peace they know not; and there is no judgment in their goings: they have made them crooked paths: whosoever goeth therein shall not know peace. [9] Therefore judgment is far from us, neither does justice overtake us: we wait for light, but behold obscurity; for brightness, but we walk in darkness. [10] We grope for the wall like the blind, and we grope as if we had no eyes: we stumble at noonday as in the night; we are in desolate places as dead men. [11] We roar all like bears and mourn sore like doves: we look for judgment, but there is none; for salvation, but it is far off from us. [12]

For our transgressions are multiplied before thee, and our sins testify against us: for our transgressions are with us; and as for our iniquities, we know them; [13] In transgressing and lying against the Lord, and departing away from our God, speaking oppression and revolt, conceiving and uttering from the heart words of falsehood. [14] And judgment is turned away backward, and justice standeth afar off: for truth is fallen in the street, and equity cannot enter. [15] Yea, truth faileth; and he that departeth from evil maketh himself a prey: and the Lord saw it, and it displeased him that there was no judgment. [16]
And he saw that there was no man, and wondered that there was no intercessor: therefore his arm brought salvation unto him; and his righteousness, it sustained him. [17] For he put on righteousness as a breastplate, and a helmet of salvation upon his head; and he put on the garments of vengeance for clothing, and was clad with zeal as a cloke. [18] According to their deeds, accordingly he will repay, fury to his adversaries, recompense to his enemies; to the islands he will repay recompense. [19] So shall they fear the name of the Lord from the west, and his glory from the rising of the sun.

When the enemy shall come in like a flood, the Spirit of the Lord shall lift up a standard against him. [20] And the Redeemer shall come to Zion, and unto them that turn from transgression in Jacob, saith the Lord. [21] As for me, this is my covenant with them, saith the Lord; My spirit that is upon thee, and my words which I have put in thy mouth, shall not depart out of thy mouth, nor out of the mouth of thy seed, nor out of the mouth of thy seed’s seed, saith the Lord, from henceforth and forever.

Absolutely. The falling away is real and it is happening right now. In fact it was already working in Paul’s day. Once the reprobates realize God’s Word is the root of their problem, and is what’s stopping reality from becoming a full blown habitation of devils with every foul spirit and a cage of every unclean bird, they will war with us. Matthew 24:8-9 KJV

All these are the beginning of sorrows. [9] Then shall they deliver you up to be afflicted and shall kill you: and ye shall be hated of all nations for my name’s sake.

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ALERT  Lightning bolt strikes One World Trade Center New York City April 1 2023 – YouTube

Doesn’t this happen every year or two?

2018 https://youtube.com/shorts/463pix3y…

2017 https://youtu.be/E-zWRx-PPXM

2014 https://youtu.be/zOC0nmcKPco

2015 https://youtube.com/shorts/rAYv8SkQ…

A year ago https://youtu.be/hI7ev5YcErQ

3 years ago, https://youtu.be/Ue1Q4IPLnz8 Etc.… there’s more.

42AVCM38P@42AVCM38P·37mReplying to @JackPosobiec

My wife and I were attending the 1700 mass today and as you know it’s Palm Sunday. During the Passion of Christ there came heavy thunder followed by a downpour. Lititz PA And signs and portents will appear in the heavens It’s a sign that he is sending all of us to either get this evil administration out of office or to return and burn this shit hole to the ground. It’s our responsibility to get this country back to God or He’s going to destroy it once and for all.

The storm is here:
That’s a Huge Positive Discharge of over 3 billion volts with 4 secondary discharges and a fireball in the middle of the return stroke on the first one, neutralizing negative effusion in the atmosphere for 50 miles in all directions in the severe front as it moves off the coast.
That was a discharge from the building. From the building it spread out everywhere. Either it’s fake or it came from that tower in my opinion. Lightning doesn’t strike like that. Maybe the frequency from the tower promoted the strike…. Pretty weird though.

This is a rare phenomenon over NYC in this form.
They try to persecute President Trump during the Holy Week just like Jesus was persecuted, The Father from Heaven will not leave them alone.

Trump will rise from the Dead heads Acts 2:19.

Please humble yourselves, turn from your wicked ways and pray!

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Lunar eclipses 2023 — When, where & how to see them | Space

In 2023, Earth will experience two lunar eclipses. The next lunar eclipse will be a penumbral lunar eclipse on May 5 and will be visible across parts of Africa, Asia and Australia. The second will be a partial lunar eclipse on October 28 and will be visible across parts of E. Americas, Europe, Africa, Asia and Australia.   Lunar eclipses occur when Earth is positioned between the sun and the moon and casts a shadow across the surface of the moon. 

They can only occur during a full moon and make for an interesting skywatching target. The last total lunar eclipse that occurred on November 8, 2022, thrilled skywatchers worldwide, the next total lunar eclipse — also known as a blood moon lunar eclipse — won’t happen until March 13/14, 2025. So that God will look down from heaven and heal our land. You do realize not everyone believes in your god nor should they have to. People keep shoving religion down people’s throats and that’s just going to push them away. I feel bad for what happened to this girl and yes while the shooter was trans, that does not define everyone. Lyrics If this World by Jaci Velasquez – YouTube

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Sodom Gomorrah – Search (bing.com)

34 “Can you shout to the clouds and make it rain? 35 Can you make lightning appear and cause it to strike as you direct? 36 Who gives intuition to the heart and instinct to the mind? 37 Who is wise enough to count all the clouds? Who can tilt the water jars of heaven 38 when the parched ground is dry, and the soil has hardened into clouds?

Job 38:34-38 His lightning lights up the world; the earth sees and trembles. Psalm 97:94 He is who makes the clouds rise at the end of the earth, who makes lightnings for the rain and brings forth the wind from his storehouses. Psalm 135:7 Our God is an awesome God. The heavens declare the glory of the Lord!

The Love of God – YouTube

💓

The Love of God w/ Lyrics (Mercy Me) – YouTube

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NO April’s Fools Joke

America and the Taliban’: 3-Part Docuseries Premieres April 2023 | FRONTLINE

GOVERNMENT AND BUSINESS HAS A SINISTER SIDE TO IT IN THIS COUNTRY 🙁
There is no story in twentieth-century history more important to understand than Hitler’s rise to power and the collapse of civilization in Nazi Germany. With The Coming of the Third Reich, Richard Evans, one of the world’s most distinguished historians, has written the definitive account for our time. A masterful synthesis of a vast body of scholarly work integrated with important new research and interpretations, Evans’s history restores drama and contingency to the rise to power of Hitler and the Nazis, even as it shows how ready Germany was by the early 1930s for such a takeover to occur. The Coming of the Third Reich: Richard J. Evans: Amazon.com: Books is a masterwork of the historian’s art and the book by which all others on the subject will be judged.

CORRUPTION AT THE D.A. Office in N.Y.C.
NYC District Attorney Alvin Bragg – Bing video

Alvin Leonard Bragg Jr. (born October 21, 1973) is an American politician and
lawyer from New York City who is serving as the New York County District Attorney, covering Manhattan. In 2021, he became the first African American elected to that office.[1] Bragg had previously served as chief deputy Attorney General of New York and as an assistant United States Attorney in the Southern District of New York.

Early life and education
Bragg is from Harlem, and grew up on Striver’s Row.[2] In an interview with The American Prospect, Bragg said that he had been “deeply affected by the criminal justice system – most directly through three gunpoint stops by the NYPD.”[3] He graduated from the Trinity School[4] before attending Harvard College. He graduated from Harvard cum laude with a Bachelor of Arts in government in 1995,[2][5] and earned his Juris Doctor from Harvard Law School, where he was an editor of the Harvard Civil Rights–Civil Liberties Law Review.[5][4]

Early career
Bragg clerked for federal district judge Robert P. Patterson Jr. before he joined the law firm Morvillo Abramowitz Grand Iason & Anello as an associate, where his work focused on white collar fraud and civil rights issues. In 2003, he joined the office of the Attorney General of New York under Eliot Spitzer before becoming the chief of litigation and investigations for the New York City Council. In 2009, Bragg left the city council to
serve as assistant United States Attorney in the Southern District of New York.[6]

In 2017, Eric Schneiderman, then serving as attorney general, appointed Bragg Chief Deputy Attorney General of New York.[7] Bragg ran the criminal justice and social justice divisions, overseeing lawsuits brought by the state against the Donald J. Trump FoundationHarvey Weinstein and The Weinstein Company, and the addition of a citizenship question on the 2020 United States Census.
He left the position in December 2018[8] and became a professor at the New York Law School, where he was co-director of the Racial Justice Project.[6] Bragg is a member of the board of directors for the Legal Aid Society. He has represented the families of Ramarley Graham and Eric Garner in civil litigation against New York City.[9]

New York County District Attorney
In June 2019, Bragg started his candidacy for the 2021 Democratic Party nomination for New York County District Attorney, then held by Cyrus Vance Jr.,[8] who did not to
run for reelection.[10] 
Following the June 22, 2021, Democratic primary, Bragg led in the reported vote count and Tali Farhadian Weinstein conceded the primary to Bragg on July 2.[11] On November 2, 2021, Bragg defeated Republican Thomas Kenniff in the general election, becoming the first African American to be elected New York County District Attorney.[1]
Bragg was sworn into office on January 1, 2022.[12]

Policies on low-level offenses
On January 4, 2022, after three days in office, he announced that his office would no longer prosecute low-level offenses such as fare evasion, resisting arrest, prostitution, and cannabis-related misdemeanors unless accompanied by a felony charge. He also decided to seek lesser charges for burglaries and store robberies where the offender “displays a dangerous instrument but does not create a genuine risk of physical harm”.[13] On January 20, Bragg disputed what he described was a “legalistic” interpretation of his prosecution policy memo and indicated that he supported a zero tolerance policy for violent crimes.[14]

Donald Trump prosecution
Main articles: New York criminal investigation of The Trump Organization 
and Indictment of Donald Trump. On February 23, 2022, Carey R. Dunne and Mark F. Pomerantz, the lead prosecutors in the New York County District Attorney’s investigation into Donald Trump and his businesses, resigned abruptly after Bragg “indicated to them that he had doubts about moving forward with a case against Mr. Trump”.[15] 
In his letter of resignation, Pomerantz wrote that the “team that has been investigating
Mr. Trump harbors no doubt about whether he committed crimes,[16] including falsifying business records, and that it was “a grave failure of justice”[16] not to pursue criminal charges.[17]

The New York Times reported that Bragg “balked at pursuing an indictment against
Mr. Trump” and lacked confidence proving in court that Trump “knowingly falsified the value of his assets on annual financial statements.”[17] 
The Washington Post noted that Bragg was slow to meet with Dunne and Pomerantz
after taking office and when they finally met to discuss the case, a source in the D.A.’s
Office commented that Bragg seemed distracted & disengaged, continually checking
his cell phone (allegations Bragg’s spokesperson denied).[18]

On November 21, 2022, The New York Times reported that the district attorney’s
office “has moved to jump-start its criminal investigation” into Trump’s reported
“hush-money payment to a porn star who said she had an affair with Mr. Trump.”[19] 
Bragg confirmed to CNN in January 2023 that the probe was ongoing.[20] 
On January 30, the office presented evidence to a grand jury regarding
Trump’s role in the payment.[21]

Jose Alba prosecution
On July 7, 2022, Jose Alba, a bodega clerk, was attacked by a customer in a dispute
over a bag of potato chips. Alba attempted to de-escalate, but after being shoved into a wall, defended himself with a knife, killing the assailant.[22] Bragg, in his prosecutorial discretion, decided to charge Alba and requested bail at $500,000; the judge set it at $250,000.[23][24] The dead attacker’s girlfriend also stabbed Alba with her own knife, after attempting to turn Alba’s knife back on him. Bragg declined to charge her.[22] After intense backlash, Bragg ultimately decided to drop the charges against Alba, noting that “a homicide case against Alba could not be proven at trial beyond a reasonable doubt”.[25]

Steve Bannon prosecution
On September 6, 2022, The Washington Post reported that Steve Bannon would be indicted on September 8 by Bragg’s prosecutors on the same charges of fraud that he was federally pardoned for by then-President Trump in 2020.[26] 
On September 8, Bannon was charged with “defrauding Americans who wanted to contribute to construction of a southern border wall, resurrecting a threat Mr. Bannon seemed to have escaped with a 2021 presidential pardon”; Bannon pleaded not guilty.[27]

Personal life
Bragg married Jamila Marie Ponton in 2003.[28] They have two children.[5] 
Bragg at one time taught Sunday School at the Abyssinian Baptist Church.[29]

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George Soros and Alvin Bragg.

President Donald Trump, writing on Truth Social, said that the Manhattan District Attorney’s office’s “leader is funded by George Soros.” The leader of that office is Alvin Bragg, the Democratic DA who took office in January 2022, according to Ballotpedia.
In the Truth Social post, Trump also wrote that he expects to be arrested on Tuesday,
and he criticized the prosecutor’s office as being highly political.

Is it true? Was Bragg funded by Soros?
Fox News reported that Soros “funneled $40 million dollars into district attorney campaigns nationwide, and now his beneficiaries represent around 20% of Americans,” including Bragg on that list.
Here’s what you need to know: According to The New York Post, former New York Police Commissioner Bill Bratton spoke out against the “$1 million donation that Hungarian-born philanthropist Soros gave to the Color of Change political action committee, which supported Bragg.”
“If you look at every city in America that has violent crime increases and disorder increases…what is the one common denominator?” Bratton said to The Post.
“District attorneys, almost all of whom are funded phenomenally by George Soros.”
The New York Post reported that “Soros also donated $1 million to Alvin Bragg’s successful DA campaign in Manhattan, funneling the cash through the Color of Change political action committee.”

The Gothamist also reported:
 “Color of Change PAC, a group that since 2016 has successfully backed reform-minded prosecutors across the country from Philadelphia to Michigan to Atlanta, announced they’d be pitching in $1 million dollars through their political action committee to put towards mailers, canvassing, and phone-banking on Bragg’s behalf.”
The National Police Association accused Soros of funding “ultra-leftist prosecutors
like Alvin Bragg (New York City), Kim Foxx (Chicago), Larry Krasner (Philadelphia),
and George Gascon (Los Angeles),” blaming the trend for rises in violent crime.

Color of Change endorsed Bragg, writing,
Update: Manhattan DA Alvin Bragg won the November 2021 general election with over 83% of the vote. He assumed office on January 1, 2022, and his current term ends on January 1, 2026.
Alvin Bragg (D) is an experienced attorney and a former chief deputy attorney general of New York. For over twenty years, Bragg has committed himself to defending the rights of New Yorkers without status or power.
He is running to become the next Manhattan District Attorney to bring his professional and lived experiences to the forefront of criminal justice reform. If elected, Bragg would become the first Black District Attorney to lead the Manhattan DA’s office.
As a lifelong Harlem resident and the only Black man in this race, Alvin Bragg has had direct encounters with the criminal legal system that have shaped his understanding of injustices and informed his policy positions.
Growing up in Harlem, Bragg experienced and witnessed violence firsthand.
As a teenage boy, Bragg was repeatedly stopped and frisked by the NYPD, including 3 times at gunpoint. He’s seen loved ones arrested and has opened his own home to support a close family member post-incarceration. 

The endorsement post, on a page called Voting While Black, reads:
Alvin Bragg uniquely understands the inequities embedded into our broken criminal justice system, and will work to reverse the effects of mass incarceration. As the next Manhattan DA, Alvin Bragg has pledged to:
Hold police accountable by creating a specialized unit to investigate police misconduct and publicly report findings.
Decline to prosecute low-level offenses for which there is no public safety benefit.
Prioritize harm-reduction strategies, including treatment for mental illness and substance use disorders.
Track racial disparities in our criminal justice system and provide training throughout the DAs office to eliminate them.
Reduce the number of guns on the streets by cracking down on gun trafficking and using outreach programs to engage communities and deter violence.
Create an independent, transparent Conviction Integrity Unit dedicated to reviewing and overturning convictions of innocent people who’ve been wrongfully accused. 
Read Bragg’s office biography here. See the campaign finance database here. 
 
Great Depression Lessons For The Coming Hard Times – YouTube
THE GREAT DEPRESSION STARTED ON THURSDAY 11 DEC 1930 WHEN THE FED REFUSED TO LEND MONEY TO THE “BANK OF UNITED STATES” AT 77 DELANCEY STREET IN MANHATTAN, NEW YORK CITY. IN OTHER WORDS, THE FEDERAL RESERVE CAUSED THE GREAT DEPRESSION ! ! ! 🔷.🔷.🔷.

.🔷 🇺🇸 Marc J. Metivier 🇺🇸

Wow! Anyone else see the similarities to what’s happening in 2022?

One of the best, and I think, most realistic movies chronicling life during the
“dirty thirties” was “The Grapes of Wrath”. My father, who grew up in a farming
family during that period, really identified with the farmers’ plight in that movie.
Henry Fonda deserved an Oscar for his performance in that movie.

My grandma remembered it well as she was born in 1925.
When she was a kid, she told her teacher of how she and her family didn’t
have enough money for food, so her teacher went to the store with her and

bought a full paper bag worth of groceries for her to take home. ❤

As she got older and had kids in the 1940s and 1950s and then later becoming my grandma by 1992, she would always make great depression type meals like noodle dishes, German potato salad, and lime jello with peas in it. Depression food was beans and rice. She must have had a middle class experience, if she was able to stay in school.

The history of Social Security published in the 1970s reported that 30% of the USA population literally starved to death or died from shortages of medical services.
The majority were children. The book explained that is what it took to motivate the creation of Social Security. Because Social Security and unemployment insurance create the foundation of the US economy, depressions are NOT likely here.

That doesn’t make sense. And bad as it was, people definitely went hungry, there wasn’t
a mass famine that killed 30% of the country. Also not lots of rice grown in America, it’s potatoes and corn. And social security and EI while good safety nets are not the foundation of the US economy. That’s crazy talk. If they had paid the farmers for the excess produce and distributed it to the starving, that would not have happened.

It is always about money and greed. There is enough food for everyone, but corruption
and greed intentionally prevent some from having enough to eat. I don’t agree with your statement that government payments can prevent depression. When there are shortages and inflation climbs, if those payments get increased that drives inflation even higher. Food shortages are coming so anyone who likes eating better starts producing or supporting locals who will.

My father told me that the day the market crash they was in town, everyone was running to the bank, he said that my grandfather to started laughing, He never kept money in the bank never trusted the banking system when he was a kid his father lost all his money in a bank robbery, My father said that my grandfather turn to my grandmother laughing really loud and said, well I think we are the richest family in the county now, my grandfather kept all the money in a mason jar buried in the barn, by the time the depression was over they still had money left.

Not during the “coming year,” according to the International Monetary Fund.
They call for a 2 to 4% reduction in the global economy.
That is not enough to start a depression. The World Bank says the worst to come in the next 12 months would be recessions. The window of risk of a Global Great Depression has been pushed back to July 2023 to July 2025. We were warned in June 2021 that we were to be monitoring the global economy from January 2023 to July 2025 for any indications of a developing Global Great Depression.

That Is based on pandemic disruptions of economies.
In December 2021, 40% of the world economy was in recession, including Russia, the Americas but not the USA, 14 nations in Europe, East Asia but not Japan. Afghanistan was not mentioned, but families had reported selling children to meet expenses. When the 35 richest nations reported in spring 2021 that they lacked money to fight the pandemic after 2022, Biden took it upon himself to avert a Global Great Depression.

We have been told in June 2022 that the US economy is now stronger than it has ever been. Consumers have caused inflation by going $16,000,000,000,000 in debt. The USA federal national debt has been reduced by Biden to $1 trillion. That is 1/16th of consumer personal debt. One to 2 relevant articles have been published each month, appearing in smartphone free news app news feeds in cities. Business tab. Rural areas don’t seem to get those.

But a person can check online every week or 2.
Search terms can be ‘ recession predictions’ or ‘Global Great depression.’ A person can add a year number. However, note that during election years, a traditional Republican Big Lie is that the economy is in shambles. They hire financial analysts to write negative articles with economics vocabulary to impress the public. Affluent are hoarding. But they are running out of needs, so retail is starting to tank. Some good sales are said to be Begin by clearing excess inventory.

Because the USA has 40,000,000 who are 18 to 27, the USA is unlikely to have a depression. Another 4,000,000 turn 18 each year through 2035. The USA had 100,000,000 born 1996 to 2020–our largest ever work force. They make any USA depression unlikely! Many of the current homeless are refugees from Red States. Red States experience chronic lack of liquidity in their economies because low wages being offered keep workers poor. We are teetering between hyperinflation and a Great Depression at this point.

What I find crazy is our government was paying farmers not to grow food while China

and The Soviet Union was starving to build their infrastructure. 🤯🤷‍♂️

Its called conserving the soil.
You can’t plant year after year on the same plot, the soil gets depleted. It’s a lesson from the dust bowl. you can but you have to rotate crops so you replenish what one crop depletes. But you can’t grow the same crop on the same land endlessly. To raise the price of the crops beyond the price of growing it. You don’t “conserve soil” by NOT PLANTING, at all. You leave a few acres barren for a couple years, then plant those acres and leave others barren. Kind of like “rotating the tires on your car.

Yeah, and right now the Dutch government wants to get rid of the biggest farming companies, because of so-called environmental reasons…;-/
On the government’s Bureau of Labor Statistics (BLS) web site, there is a category for “No Longer in the WorkForce’. There are currently one hundred million working-age Americans (18-65) listed. That’s four times the maximum unemployment during the Great Depression, and does not include today’s “official” unemployed numbers, which add another 6.7 million. Soon we’ll be remembering the Great Depression as “the good old days”.

That can’t be accurate as the USA only has 113.9 million people in That are group. Your numbers would mean only 7 million people are working and over 94% of the rest are not. H5mind: 5 million are in college/university. 5 million are in community college. 15 million are on Social Security Survivor it Disability. 6 million have retired at 62.

Civil servants, military, public school teachers, and mass transit workers retire after 20 years of service. Those get their pensions as young as about 45 to 50. Many affluent stop working when they become adequate investors. Right now (June 2022), there are 3 vacancies for every person on unemployment. You are not analyzing that 100,000 extensively enough. Grandpappy tells of a farmer who made his fortune with farm subsidies.

He was paid to not grow wheat on 80 acres of his land. Great! But that left the land available for growing corn. But instead, he made more by being paid to not grow corn on those 80 acres. And then, paid again to not grow soybeans on that same land. And again, to not grow canola. And again, to not grow safflower. And again, to not grow sunflowers. And again, to not grow cabbages.

So many young folks who just do not even want to hear about those times. They will be frantic! Those who want easy jobs and think being an influencer, an artist, a home-based worker etc. will be hurting. $100. sneakers, expensive fancy nails and hair care, daily outings to eat, constant fancy fashions, luxury upon luxury will end.


Looking at this very interesting report, I kept wondering why it focused so exclusively on white Americans. Thinking about it I realized that there must not be much film material on the life of black Americans at the time and that there was indeed nothing special to report about their life during the great depression because it was not much different to what they experienced over a whole century after the end of the civil war.

Biden Gifts The Taliban $80 Billion U.S. Military Equipment – Search (bing.com)

Obama’s Connection to the Muslim Brotherhood – Search (bing.com)

Jesus Christ is the son of God who died and rose three days later and loves all of you.
He died for everyone and wants you with Him, to know Him and live for His glory.
Come be saved eternally and spend time with Him to know Him. Be saved, free, forgiven, healed, delivered, baptized, whole and let Him show you how He is everything you need.


🕊️💕Live righteous and Holy because He said to and paid for our way to live like Him. Ask anything in His name and the Father will do it amen hallelujah praise God thank you Jesus. 🙏

I lift up everyone’s prayers, wants and needs to You Jesus, please pour out blessings.
May Your favor, grace and mercy be upon the world. In Jesus name come help us all.
You know our needs and everything else about each of us.

In Jesus name amen thank you Jesus praise God 🙏

Jesus, Help people to be rooted and grounded in Your love and to obey Your truth.
That they are living in the truth being taught by You.
That they know Your voice and word. Knowing truth from errors, discernment. 💕


We are ambassadors of Christ. We represent God, when we are seen Jesus should be seen, His ways not ours. We should be living for and showing God, living for His glory. We are to be an example of Jesus for the world to see Him and want to know Him and know Him more. 🙏 🔥


2 Chronicles 7:14 says, if My people humble themselves and pray and seek My face and turn from their wicked ways, I will hear them from heaven and heal their land. 🙏 💖


People need to turn from their wicked ways, Jesus paid for it. That’s God stating it in that verse and there are more verses. People need to repent, to be cleansed by His blood and live Holy because He’s Holy and righteous because He’s righteous. Our God said to stop sinning in many, many scriptures and He paid for everyone to be cleansed of sin (Isaiah 53), and to live how He said. He dwells in the Holy temple (your body) and said not to defile the temple. He said to defile the temple is death. He’s always serious about everything He said to do. He’s just as serious about what He said not to do. We live in obedience to His law, every word if it! He dwells within us all to be with and leads us in His ways. 💕🙏🔥 🕊️

Deuteronomy 28 there are blessings for obedience and curses for disobedience. The whole chapter, and verse 46 is one example of generational curses. These go into the following generations, the 3 and 4th. Our children pay the price for our sin. Stop sinning, you are sending consequences to yourself and to your loved ones, children. By God’s law you are.
If you don’t believe me, ask Him, in Jesus’ name may you see and know the truth in its fullness.

Love your neighbor as you love yourself.

Jesus is worthy of everything He said and paid for, so I implore you to do as God said.
Jesus said If you love me, you will obey my commands. Love Him with all your heart, mind, soul and strength. 💖🔥🕊️ 🙏


Praise God 🙏💖 Hallelujah Jesus🙏💖


In Jesus powerful name🙏🔥🕊️ 💖


Lawrence Welk Show Jan. 14, 1976 – 200 Years Of American Music, Part 1 – YouTube
Lawrence Welk Show Jan. 24, 1976 – 200 Years of American Music,  Part 2 – YouTube
Lawrence Welk Show – A Century of American Music at the Branson Theater in 2000…
“Seven Spanish Angels” Tribute Brings Willie Nelson Close To Tears (pitbullworld.net)



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New Way to Shrink Tumors

IMIPRAMINE SHRINKS CANCER TUMORS
This Blog Post Will Require a Bit more research on your part to fully understand!!
Find out how an old drug may have a new life-saving purpose when it comes to treating malignant tumors. Good news for the nearly 267 thousand men and women who are diagnosed with breast cancer each year in the United States.

Frontiers | Suppression of EGFR/PKC-δ/NF-κB
Signaling Associated With Imipramine-Inhibited
Progression of Non-Small Cell Lung Cancer (frontiersin.org)

FDA-approved antidepressant may combat deadly form of lung cancer,
study finds | News Center | Stanford Medicine
by  Krista Conger is a science writer for the medical school’s
Office of Communication & Public Affairs. in September 26, 2013

Krista Conger
In another study Imipramine Inhibits Migration and Invasion in Metastatic Castration-Resistant Prostate Cancer PC-3 Cells via AKT-Mediated NF-κB Signaling Pathway
by Eun Yeong Lim  1,2, Joon Park  1,2, Yun Tai Kim 1,2,* and Min Jung Kim 3,*

1. Research Group of Functional Food Materials, Korea Food Research Institute,
245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Korea
2. Department of Food Biotechnology, Korea University of Science & Technology,
217 Gajeong-ro, Yuseong-gu, Daejeon 34113, Korea
3. Research Group of Natural Materials and Metabolism, Korea Food Research Institute,
245, Nongsaengmyeong-ro, Iseo-myeon, Wanju-gun, Jeollabuk-do 55365, Korea
* Authors to whom correspondence should be addressed.

Molecules 202025(20), 4619; https://doi.org/10.3390/molecules25204619
Received: 18 September 2020 / Revised: 9 October 2020 / Accepted: 10 October 2020 / Published: 11 October 2020
(This article belongs to the Collection Efficient Pharmaceutical and Chemical Approaches for Anticancer Therapy: Design, Preliminary Evaluations, and Further Developments

Abstract
Imipramine (IMI) is a tricyclic synthetic antidepressant that is used to treat chronic psychiatric disorders, including depression and neuropathic pain. IMI also has inhibitory effects against various cancer types, including prostate cancer; however, the mechanism of its anticancer activity is not well understood. In the present study, we investigated the antimetastatic and anti-invasive effects of IMI in metastatic castration-resistant prostate cancer PC-3 cells, with an emphasis on the serine/threonine protein kinase AKT-mediated nuclear factor kappa B (NF-κB) signaling pathway. 
While IMI did not induce cell death, it attenuated PC-3 cell proliferation. According to the wound healing assay and invasion assay, migration and invasion in PC-3 cells were significantly inhibited by IMI in a dose-dependent manner. IMI significantly downregulated p-AKT protein expression but upregulated phospho-extracellular signal-regulated kinase (ERK1)/2 protein expression levels. 
Furthermore, IMI treatment resulted in decreased AKT-mediated downstream signaling, including p-inhibitor of κB kinase (IKK)α/β, p-inhibitor of κB (IκBα), and p-p65.
Inhibited NF-κB signaling reduced the secretion of several proinflammatory cytokines and chemokine by PC-3 cells. Overall, our study explored the negative correlation between the use of antidepressants and prostate cancer progression, showing that IMI attenuated cell viability, migration, and invasion of PC-3 cells by suppressing the expression of AKT and NF-κB-related signaling proteins and secretion of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1).

Keywords: 
imipramineantidepressantsprostate cancermigrationinvasion

Graphical Abstract

1. Introduction
Prostate cancer is one of the most common invasive cancers in men,
with 1,276,000 cases and 359,000 deaths worldwide in 2018 [1].
In Korea, the incidence of prostate cancer has more than doubled in the last 15 years due to the aging population and the westernization of eating habits [2]. Patients with localized prostate cancer are managed by radiation therapy, surgery, or hormone therapy, while locally advanced prostate cancer and metastatic prostate cancer are mainly treated with androgen-deprivation therapy (ADT) [3]. 
ADT leads to the remission of prostate cancer in about 90% of the patients
as evidenced by decreased circulating levels of prostate-specific antigen (PSA) [4]. 
However, continuous ADT treatment attenuates the response of metastatic castration-sensitive prostate cancer (mCSPC) to ADT within 12–24 months and causes changes in the types of metastatic prostate cancer from mCSPC to metastatic castration-resistant prostate cancer (mCRPC) [5,6]. 
mCRPC is associated with a high risk of morbidity and mortality, with a short survival time of only 16–18 months [7]. 

Therefore, it is urgent to suppress mCRPC and develop new efficient chemotherapeutic agents for the treatment of ADT-resistant mCRPC.
Food and Drug Administration (FDA)-approved chemotherapeutic drugs for mCRPC are mitoxantrone, docetaxel, and cabazitaxel. Mitoxantrone, approved in 1996, had a palliative benefit and decreased PSA levels [8,9,10].
 Subsequently, docetaxel and cabazitaxel, approved in 2004 and 2010, respectively, replaced mitoxantrone; these drugs relieved symptoms, improved PSA response rate, and led to extended overall survival in mCRPC patients [9,11,12,13]. 
However, both of these drugs also have limitations because some patients with mCRPC are not controlled by these drugs, and resistance to treatment eventually occurs. To overcome these disadvantages, researchers are constantly exploring new chemotherapeutic agents.
One of the suggestions that resulted from these efforts is to use antidepressants as new mCRPC inhibitors. Several classes of antidepressants exist, such as nonselective monoamine reuptake inhibitors, selective serotonin reuptake inhibitors, nonselective monoamine oxidase inhibitors, monoamine oxidase A (MAO-A) inhibitors, and other antidepressants including tricyclic antidepressants (TCAs) [14,15]. 

Among these, MAO-A inhibitors are known for their efficacy and mechanisms of prostate cancer suppression [16,17].
MAO-A inhibitors, including clogyline and mocrobemide, suppressed the activation of Shh-interleukin 6-receptor activator of nuclear factor kappaB ligand (Shh–IL6–RANKL) signaling, further suppressed the metastasis of CRPC cells, and prolonged overall survival in patients in preclinical studies [16]. In addition, antiandrogen enzalutamide-resistant mCRPC cells derived by chronic exposure to enzalutamide could be re-sensitized to enzalutamide by treatment with MAO-A inhibitors such as phenelzine and clorgyline [17]. However, the efficacy and mechanisms of action of TCAs in mCRPC cells have been poorly studied.

Imipramine (IMI, 10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride) is a member of the TCA family and is used in the treatment of depressive disorders, neuropathic pain, and nocturnal enuresis [18,19,20]. 
In addition to these neurologic properties, IMI has exhibited antiproliferative and anticancer activities in various cancer cells such as myeloma, small-cell lung cancer, pancreatic neuroendocrine cancer, and prostate cancer cells [21,22,23]. 

However, the mechanism of IMI action in prostate cancer, especially mCRPC, has not been fully studied. The only known mechanisms of IMI action involve the inhibition of the voltage sensitive ether-à-go-go potassium (EAG 1) channel activity in one of the mCRPC cell lines, DU145, reduction of cell proliferation, and induction of apoptosis [23].
Therefore, the aim of this study was to investigate the effects and mechanisms of IMI action during the migration and invasion in PC-3 cells, which can be considered as a cellular model of mCRPC because they are androgen-insensitive and have a high metastatic potential.

2. Results
2.1. IMI Inhibits Proliferation of PC-3 Cells without Causing Cell Death
The antiproliferative properties of IMI were evaluated by exposing the prostate cancer cell line PC-3 to different concentrations of IMI (3.8 × 10−4 to 1.0 × 102 μM) for 12 h and 72 h. IMI treatment resulted in decreased proliferation of PC-3 cells in a dose-dependent and time-dependent manner (Figure 1a). In the IMI-treated group at 12 h, IMI at < 10 μM did not affect cell proliferation; however, concentrations above 10 μM resulted in decreased cell proliferation in a dose-dependent manner. 
In the IMI-treated group at 72 h, IMI had a dose-dependent inhibitory effect on cell proliferation over the entire dose range. To confirm cell viability, PC-3 cells were treated with the highest concentration (100 μM) of IMI for a longer period (72 h), and the cell viability was visualized using a LIVE/DEAD kit and quantified (Figure 1b,c).
Although PC-3 cells were exposed to high doses for a long period, the number of live
and dead cells and cell viability in IMI-treated cells did not show significant differences compared to those in the untreated cells. We concluded that IMI did not induce cell death but attenuated the proliferation of PC-3 cells.
Molecules 25 04619 g001 550
Figure 1. Effect of imipramine treatment on proliferation of PC-3 cells.

 (a) PC-3 cells were treated with 3.8 × 10−4 to 1.0 × 102 μM imipramine (IMI)
for 12 h and 72 h, and cell proliferation was evaluated using a water-soluble tetrazolium salts, WST-1 assay.
 (b,c) Cell viability at 100 μM of imipramine treatment for 72 h was visualized and quantified using a LIVE/DEAD kit. Green and red fluorescence indicates live and dead cells, respectively. n.s.: not significant.
2.2. IMI Inhibits PC-3 Cell Migration
To determine whether IMI inhibits migration in PC-3 cells, wound healing was monitored in PC-3 cells treated with different concentrations of IMI (6.25, 12.5, 25, 50, and 100 μM). As shown in Figure 2b,c, IMI significantly decreased the migration of PC-3 cells in a dose-dependent manner compared to that in the control, untreated cells (p < 0.001).
These results demonstrated that IMI suppressed migration in PC-3 cells in vitro.
Molecules 25 04619 g002 550
Figure 2. Inhibition of cell migration and invasion by imipramine. 

(a) PC-3 cells were treated with imipramine (0–100 μM) for 12 h.
Representative images of the cells treated with the indicated doses
were acquired in an optical microscope after the wounding.
 (b) The percentage of wound recovery was normalized to untreated control cells.
 (c) PC-3 cells were treated with imipramine (0–100 μM) for 12 h and the effects of imipramine on invasion were analyzed using Matrigel invasion assays.
Representative images were taken in the bottom of the Transwell filter
at indicated time points via phase-contrast microscopy.
 (d) Quantitative data of an invasion assay were expressed as the number of invasive cells. Data are presented as the mean ± standard error of the mean (SEM) and analyzed using one-way ANOVA; *** p < 0.001 compared with untreated cells.
2.3. IMI Inhibits PC-3 Cell Invasion
To determine the effect of IMI on cell invasion, PC-3 cells were treated with 12.5, 25, 50, and 100 μM IMI, after which the cells were allowed to invade in Matrigel-coated Transwells for 24 h. The number of invading cells was significantly reduced by the IMI treatment in a dose-dependent manner (Figure 2c,d). Compared to the untreated group, IMI at 50 and 100 μM suppressed cell invasion by 79.8% and 92.5%, respectively. These data clearly show that IMI is a strong suppressor of PC-3 cell invasion.
2.4. IMI Inhibits Phosphorylation of Serine/threonine Protein Kinase (AKT), but Not that of Extracellular Signal-regulated kinase (ERK)1/2 in PC-3 Cells
In order to investigate the mechanism of IMI action, the effects of IMI treatment (6.25, 12.5, 25, 50, and 100 μM) on protein expression levels of AKT and ERK1/2 were evaluated using Western blot analysis in PC-3 cells.
As shown in Figure 3, activation of AKT in PC-3 cells was significantly suppressed by IMI (6.25, 12.5, 25, 50, and 100 μM) at 48 and 72 h, as evidenced by the dose-dependent decrease in AKT phosphorylation. However, the expression of phosphorylated ERK1/2 was upregulated by IMI at 48 h and 72 h.
Molecules 25 04619 g003 550
Figure 3. Effect of imipramine on phosphorylation of serine/threonine protein kinase (AKT) and extracellular signal-regulated kinase (ERK)1/2 at 48 h and 72 h in PC-3 cells.
(a,d) Protein expression of AKT, p-AKT, ERK1/2, p-ERK1/2, and β-actin in PC-3 cells was detected using Western blotting.
(b,c,e,f) Quantitative data of phosphorylated AKT and ERK were normalized to the untreated cells. Data are presented as the mean ± SEM (n = 3) and analyzed using one-way ANOVA; * p < 0.05, and *** p < 0.001 compared with untreated cells.
2.5. IMI Attenuates Nuclear Factor Kappa B (NF-κB) Signaling and the Expression of Proinflammatory Cytokines and Chemokines in PC-3 Cells
Cancer proliferation is associated with NF-κB signaling pathway and inflammatory cytokines. The protein expression levels of p-inhibitor of κB kinase (IKK)α/β, IKKα, p-inhibitor of κB (IκBα), IκBα, p-p65, p65, and β-actin in the NF-κB signaling pathway, which is downstream to AKT activation, and the secretion of inflammatory cytokines were estimated using Western blotting and RT-PCR, respectively. As a result, IMI inactivated the NF-κB signaling pathway in PC-3 cells (Figure 4a–e). Phosphorylation of IKKα/β, IκBα, and p65 was inhibited by IMI. Concurrently, degradation of IκBα was reduced by IMI. In particular, phosphorylated p65 levels were significantly attenuated in response to IMI treatment (25–100 μM) in a dose-dependent manner.

Molecules 25 04619 g004 550
Figure 4. Effect of imipramine on protein phosphorylation during nuclear factor kappa B (NF-κB) signaling and the expression of inflammatory cytokines at 48 h in PC-3 cells.

 (a) Protein expression of p-inhibitor of κB kinase (IKK)α/β, IKKα, p-inhibitor of κB (IκBα), IκBα, p-p65, p65, and β-actin in PC-3 cells was detected using Western blotting.
 (b) Quantitative data of phosphorylated IKKα/β were normalized to the untreated cells.
 (c) Quantitative data of phosphorylated IκBα were normalized to the untreated cells. 
(d) quantitative data of IκBα were normalized to the untreated cells.
 (e) Quantitative data of phosphorylated p65 were normalized to the untreated cells.
 (fh) The production of tumor necrosis factor–α (TNF-α), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1) messenger RNA (mRNA) was analyzed using quantitative real-time RT-PCR. Data are presented as the mean ± SEM of three independent experiments and analyzed using one-way ANOVA; * p < 0.05, ** p < 0.01, and *** p < 0.001 compared with untreated cells.
Because protein phosphorylation during NF-κB signaling regulates the expression of inflammatory cytokines, the messenger RNA (mRNA) expression of inflammatory cytokines, including tumor necrosis factor–α (TNF-α), interleukin-1β (IL-1β), and monocyte chemoattractant protein-1 (MCP-1) was quantitatively analyzed using qRT-PCR. The mRNA levels of all three cytokines were significantly suppressed by IMI treatment (Figure 4f–h). The mRNA level of TNF-α was significantly inhibited by 100 μM. The mRNA levels of IL-1β and MCP-1 were significantly attenuated by IMI concentrations ranging from 12.5 μM to 100 μM and from 25 μM to 100 μM, respectively.

3. Discussion
This is the first study to demonstrate that IMI attenuates cell proliferation, migration, and invasion of PC-3 cells via inactivation of AKT-mediated NF-κB signaling and activation of ERK-mediated signaling. IMI suppressed the phosphorylation of AKT, IKKα/β, IκBα, and p65 in PC-3 cells in a concentration-dependent manner. Downregulated AKT-mediated NF-κB signaling was associated with decreased gene expression levels of cytokines including TNF-αIL-1β, and MCP-1. Our findings suggest that imipramine could be a potential candidate for treatment of prostate cancers.
A number of signaling pathways regulate cellular metabolism and cancer progression. The representative mechanisms involved in cell survival, growth, proliferation, migration, and invasion in tumors and tumor cell lines include the phosphatidylinositol 3-kinase (PI3K)/AKT pathway and mitogen-activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK) pathway. 

These pathways are also important for mCRPC progression. PI3K activation stimulates downstream phosphatidylinositol (3,4,5)-trisphosphate (PIP3) production and further phosphorylation of AKT (Ser473 and Thr308) in the PI3K/AKT pathway [24]. PI3K inactivation by PI3K inhibitor (LY294002) attenuated the protein expression of PI3K (p85) and p-AKT (Ser473) and further suppressed PC-3 cell invasion [25]. Selective inhibition of the PI3K/AKT pathway with the AKT inhibitor, AZD5363, also retards cellular proliferation and tumor progression in CRPC xenografts [26]. In particular, AKT is an attractive therapeutic target to inhibit mCRPC progression because of the following characteristics of PC-3 cells: (1) excessive AKT level, (2) loss of phosphatase and tensin homolog (PTEN), and (3) AKT-induced inhibition of Raf/mitogen-activated protein kinase kinase (MEK)/ERK signaling cascades. 

According to phospho-proteomic analysis in metastatic tumor samples, mCRPC contains excessive amounts of AKT protein as the most common tyrosine kinase [27]. PTEN, a tumor suppressor gene that is negatively involved in AKT phosphorylation by PI3K, is lost in ~50% of tumor tissue in mCRPC patients and is known to inhibit cell proliferation and migration in prostate cancer [28,29]. Both excessive AKT accumulation and loss of PTEN accelerate prostate carcinogenesis. Raf/MEK/ERK signaling cascades are upregulated not only by Ras activation but also by AKT inhibition in several types of cancers, such as prostate and breast cancers [30,31]. ERK signaling has two opposing roles: one is associated with cell proliferation, migration, and invasion [32], and the other one is relevant to the proapoptotic action of chemotherapeutics. 
Various antitumor agents, including resveratrol, betulinic acid, apigenin, and or oridonin, trigger cancer cell death through ERK activation [33,34,35,36]. This is consistent with other chemotherapeutic agents in which phenethyl isothiocyanate activates MAPK/ERK signaling cascades and induces apoptosis in PC-3 cells [37]. In addition, upregulated MAPK/ERK signaling by AKT inactivation also induced loss of differentiation of PC-3 cells [38]. IMI inhibited AKT phosphorylation, increased ERK activation in PC-3 cells, and attenuated cell proliferation, instead of inducing cell death.

CRPC contains higher levels of AKT and NF-κB than CSPC and other cancers.
The NF-κB family of proteins plays a pleiotropic role in controlling multiple cell functions such as proliferation, survival, cell death, invasion, and angiogenesis; however, this protein family plays a dichotomous role. The canonical NF-κB signaling pathway is executed through the activation of the IKK complex composed of the catalytic subunits (IKKα and IKKβ) and the regulatory subunit (IKKγ/NF-κB essential modifier, NEMO) [39]. 
Phosphorylated IKK activates IκBα proteins and then phosphorylates IκBα to release the p65(RelA)/p50(NF-κB1) complex, followed by degradation of IκBα by proteasome. The separated p65/p50 complex is translocated into the nucleus to activate gene transcription. Among NF-κB family proteins, not NF-κB/p50 but NF-κB/p65 is constitutively activated in human prostate adenocarcinoma. The NF-κB signaling pathway can be activated by AKT. Several studies have suggested that AKT/NF-κB signaling works together in prostate cancer cells [40,41]. 
The migration and invasion enhancer 1 (MIEN1) gene, which is highly expressed in prostate cancer cells, regulates AKT/NF-κB signaling. Phosphorylation of AKT stimulates the mechanistic target of rapamycin complex 1 (mTORC1) and the IKK/NF-κB signaling cascade in PC-3 cells. Consistent with these cascades, inactivated AKT by IMI significantly attenuated the expression levels of phosphorylated IKKα/β, IκBα, and p65 in a dose-dependent manner in PC-3 cells. p65, binding to a consensus DNA sequence in the promoter region, regulates cancer metastasis [42].
 Previous studies reported that blocking the p65 attenuated metastasis in prostate cancer; on the other hand, activation of p65 promoted invasion and migration of prostate cancer cells [43,44,45,46]. 

Moreover, suppressed AKT/NF-κB signaling by IMI affected downstream signaling cascades.
Proinflammatory cytokines and chemokines are regulated by NF-κB. Phosphorylation of p65 facilitates its binding to a specific DNA sequence, which triggers the transcriptional activation of NF-κB-regulated genes, including proinflammatory cytokine genes and chemokine genes. We found that IMI-induced deactivation of p65 also attenuated the expression levels of downstream genes, including two proinflammatory cytokine genes (TNF-α and IL-1β) and one chemokine gene (MCP-1). Prostate cancer cells express chemokine and chemokine receptors, as well as endogenously produced chemokines and cytokines such as MCP-1TNF-αIL-1β, IL-6, and IL-8 [47,48,49], 
some of which are secreted at a higher level in PC-3 cells (mCRPC cell line) than in LNCaP cells (mCSPC cell line). MCP-1, a member of the CC chemokine superfamily, is associated with recruitment and activation of monocytes during acute inflammation.
Endogenous MCP-1, eliciting both autocrine and paracrine responses, promotes cell growth and invasion in prostate cancer cells including primary prostate epithelia (PrEC), LNCaP, C4-2B, and PC-3 cells [50]. 
TNF-α and IL-1β, the major proinflammatory cytokines associated with systemic inflammation, play a critical role in tumorigenesis, tumor progression, and carcinogenesis. Both cytokines also act as autocrine factors; thus, the secretion of endogenously produced TNF-α and IL-1β promotes cell proliferation and migration in PC-3 cells. In particular, it is proof that the expression of IL-1β is stimulated by p65 phosphorylation. 
Finally, IMI-induced suppression of the expression of TNF-αIL-1β, and MCP-1 may regulate autocrine signaling and inhibit cell proliferation, migration, and invasion. In this study, we found that imipramine inhibits proliferation, migration, and invasion in a cellular model of mCRPC, which is expected to be related to AKT/NF-κB signaling. Some research suggested that upstream AKT signaling including PI3K, PDK1, and PTEN can be binding targets of imipramine [51], but further study will be needed to know the exact target of imipramine. In addition, it is necessary to observe the suppressive effect of imipramine on metastasis using a xenograft tumor model so that the results of in vitro studies can be confirmed in vivo.

4. Materials and Methods

4.1. Materials
IMI was purchased from Sigma-Aldrich (St. Louis, MO, USA). The antibody against β-actin was purchased from Santa Cruz Biotech (Santa Cruz, CA, USA). Antibodies against p-IKKα/β, IKKα, p-IκB, IκB, p-p65, p65, ERK1/2, p-ERK1/2 (Thr202/Tyr204), AKT, and p-AKT (Ser473) were purchased from Cell Signaling Technology (Beverly, MA, USA).

4.2. Cell Culture
The prostate cancer cell line PC-3 was obtained from the Korean Cell Line Bank (KCLB, Seoul, Korea) and cultured in Roswell Park Memorial Institute (RPMI) 1640 (Gibco, Grand Island, NY, USA) containing 10% fetal bovine serum (FBS; Gibco) and 100 U/mL penicillin/streptomycin (Gibco) at 37 °C and 5% CO2.

4.3. Cell Proliferation Assay
PC-3 cells were seeded in 96-well plates (1 × 103 cells/well) and cultured overnight to allow cell adhesion. PC-3 cells were treated with 0.1% dimethyl sulfoxide (DMSO) or various concentrations of IMI (range: 3.8 × 10−4 to 1.0 × 102 μM) for 12 h or 72 h. Subsequently, 10 μL of water-soluble tetrazolium salts, WST-1 reagent (Roche Diagnostics GmbH, Mannheim, Germany) was added to each well and incubated for 4 h at 37 °C in a humidified 5% CO2 atmosphere. Finally, the absorbance at 450 and 650 nm was measured using a SpectraMax Plus Plate Reader (Molecular Devices, Sunnyvale, CA, USA). PC-3 cells treated with 0.1% DMSO served as a control. The percentage of cell proliferation was calculated using the following equation:Cell proliferation = (OD450 − OD650 of IMI-treated cells)/(OD450 − OD650 of control) × 100.

4.4. Live/Dead Cell Viability Assay
Cell viability was confirmed using a LIVE/DEAD® Cell Imaging Kit (Invitrogen, Waltham, MA, USA). PC-3 cells plated at a density of 1 × 103 cells per well in a 96-well plate were treated with 0.1% DMSO or 100 μM IMI. After 72 h, calcein-AM (live, green) and propidium iodide (PI; dead, red) were added to the cells and incubated for 15 min at room temperature in the dark. Images of live and dead cells were acquired using a fluorescence microscope (Axio Observer A1; Carl Zeiss AG, Oberkochen, Germany).
The percentage of cell viability was calculated according to the following formula:% of cell viability = (the number of viable cells/the total number of cells) × 100.

4.5. Wound Healing Assay
PC-3 cells were seeded at a density of 7 × 105 cells/mL into the two wells of a culture insert (Ibidi GmbH, Martinsried, Germany). After the overnight incubation, cells were grown to full confluence, and the culture inserts were removed to make the wound gap. Cells were washed with phosphate buffered saline (PBS) and incubated with five different concentrations of IMI (0–100 μM) for 12 h. Representative images for each concentration were captured at 10× magnification using a digital camera attached to an inverted microscope to quantify the relative migration of cells (Axio Observer A1). The area of the wound was quantitatively analyzed using MetaMorph software (Molecular Devices, Sunnyvale, CA, USA), and the percentage of wound recovery was evaluated.
Coverage in untreated PC-3 cells was defined as 100%.

4.6. Cell Invasion Assay
The cell invasion assay was performed using 24-well Transwell chambers with polycarbonate filters with 8 μm pore size (Corning Costar, Corning, New York, NY, USA). Transwell chambers were coated with gelatin solution (0.1%) on the lower surface and Matrigel on the upper surface for 30 min. PC-3 cells were seeded at a density of 2 × 104 cells/mL in serum-free medium onto the upper compartment of the Transwell, and the lower chambers were filled with medium containing 10% FBS and various concentrations of IMI (12.5, 25, 50, and 100 μM). After 24 h, the non invaded cells and the Matrigel on the upper chamber were gently removed using a cotton-tipped swab; then, cells at the undersurface of the filters were stained with crystal violet stain solution for 20 min and rinsed several times in distilled water. The number of invaded cells was quantified by visual counting after being photographed using an inverted microscope at 10× magnification.

4.7. Western Blot Analysis
PC-3 cells (4 × 105 cells/dish) were seeded in 100 mm dishes for 24 h and starved with 0.05% FBS overnight. PC-3 cells were incubated with five different concentrations of IMI (3.25, 12.5, 25, 50, and 100 μM) for 48 h or 72 h. After the treatment, the cells were lysed using a cell lysis buffer (Cell Signaling Technology, Beverly, MA, USA) containing a protease inhibitor cocktail from Roche and phosphatase inhibitor (Sigma Aldrich) for 30 min on ice.
After centrifugation, a bicinchoninic acid (BCA) protein assay kit (Thermo Scientific, Rockford, IL, USA) was used to determine the protein concentration. Equal amounts of protein lysate were separated in 10% sodium dodecyl sulfate (SDS) polyacrylamide gels and transferred to a polyvinylidene difluoride (PVDF) membrane (Bio-Rad Inc., Hercules, CA, USA). 
The membrane was blocked with 5% skim milk in Tris-buffered saline with 0.1% Tween-20 (TBST) for 1 h at room temperature and then incubated with the specific primary antibodies, including AKT, phospho-AKT (Ser473), ERK1/2, phospho-ERK1/2 (Thr202/Tyr204), phospho-IKKα/β, IKKα, phospho-IκB, IκB, phospho-p65, and p65, overnight at 4 °C. The membranes were washed in TBST three times and incubated with horseradish peroxidase (HRP)-conjugated secondary antibodies at room temperature for 2 h. Protein bands were visualized using a chemiluminescence detection kit (ATTO, Tokyo, Japan). Beta-actin was used as the loading control.

4.8. Total RNA Isolation and Quantitative Reverse-Transcription Polymerase Chain Reaction (RT-qPCR)
Total RNA was isolated using the NucleoPin® RNA Plus XS Kit (Macherey-Nagel, Bethlehem, PA, USA) according to the manufacturer’s instructions. Reverse transcription of RNA was performed using the ReverTra Ace® qPCR RT Master Mix (Toyobo, Osaka, Japan). First-strand complementary DNA (cDNA) was prepared using 1 μg of total RNA. The real-time PCR reaction was performed in a volume of 20 μL containing 0.1 μg of cDNA, 1 μM of each primer (Table 1), and Power SYBR® Green PCR Master Mix (Applied Biosystems, Carlsbad, CA, USA).
Thermal cycling was carried out in a StepOnePlus Real-Time PCR system (Applied Biosystems, Carlsbad, CA, USA) with a program of 95 °C for 5 min, followed by 40 cycles of denaturation at 95 °C for 5 s annealing, and elongation at 60 °C for 10 s. Gene expression levels were normalized to the expression level of the housekeeping gene glyceraldehyde-3-phosphate dehydrogenase (GAPDH). Relative gene expression changes, calculated using the 2−∆∆CT method, were reported as number-fold changes compared to those in the control samples.
Table 1. Primer sequences for RT-qPCR.
Table

4.9. Statistics
All experiments were independently performed at least three times and the values were expressed as the mean ± standard error of the mean (SEM). Statistical analysis was performed using GraphPad Prism version 5 (GraphPad Software, Inc., La Jolla, CA, USA). Statistical significance was evaluated by unpaired t-test for comparison between two groups and one-way ANOVA followed by Dunnett’s post hoc test for multiple groups.
p-value < 0.05 was considered to indicate a statistically significant difference.

5. Conclusions
In conclusion, our results demonstrated that IMI treatment inhibited cell proliferation, migration, and invasion in mCRPC PC-3 cells. The suggested mechanisms of IMI in PC-3 cells include the modulation of AKT/ERK signaling and suppression of the AKT/NF-κB signaling pathway by preventing IκBα degradation, blocking p65 phosphorylation, and regulating chemokine and cytokine production. We suggest that IMI may be a potential chemotherapeutic candidate against metastatic CRPC.
Author Contributions
Formal analysis, E.Y.L. and J.P.; investigation, E.Y.L. and J.P.; methodology, E.Y.L.; writing—original draft, E.Y.L. and J.P.; funding acquisition, Y.T.K.; resources, Y.T.K.; supervision, Y.T.K.; writing—reviewing and editing, Y.T.K. and M.J.K.; conceptualization, M.J.K.; project administration, M.J.K. All authors have read and agree to the published version of the manuscript.

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
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MDPI and ACS Style
Lim, E.Y.; Park, J.; Kim, Y.T.; Kim, M.J. Imipramine Inhibits Migration and Invasion in Metastatic Castration-Resistant Prostate Cancer PC-3 Cells via AKT-Mediated NF-κB Signaling Pathway. Molecules 202025, 4619. https://doi.org/10.3390/molecules25204619
AMA Style
Lim EY, Park J, Kim YT, Kim MJ. Imipramine Inhibits Migration and Invasion in Metastatic Castration-Resistant Prostate Cancer PC-3 Cells via AKT-Mediated NF-κB Signaling Pathway. Molecules. 2020; 25(20):4619. https://doi.org/10.3390/molecules25204619
Chicago/Turabian Style
Lim, Eun Yeong, Joon Park, Yun Tai Kim, and Min Jung Kim. 2020. “Imipramine Inhibits Migration and Invasion in Metastatic Castration-Resistant Prostate Cancer PC-3 Cells via AKT-Mediated NF-κB Signaling Pathway” Molecules 25, no. 20: 4619. https://doi.org/10.3390/molecules25204619

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Zongjie Wang, Sharif Ahmed, Mahmoud Labib, Hansen Wang, Xiyue Hu, Jiarun Wei, Yuxi Yao, Jason Moffat, Edward H. Sargent, Shana O. Kelley. Efficient recovery of potent tumour-infiltrating lymphocytes through quantitative immunomagnetic cell sortingNature Biomedical Engineering, 2022; DOI: 10.1038/s41551-021-00820-y

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You Don’t Have to Die

You Don’t Have to Die Harry Hoxsey – Search (bing.com)

Harry Hoxsey “You Don’t Have To Die” : John Burns UMOJA Research : Internet Archive
It is very likely that you have stumbled upon this blog because 
A-You have been diagnosed with Cancer, or 
B-You know someone who has been diagnosed with Cancer.

Home – Our Cancer Journey and the Path to Healing (mashageorgiev.com)
First off, thank you for visiting my blog and taking the time to read what I have written and watch my videos on my YouTube Channel. I try to make things short and simple and to the point as much as possible so I hope that is what you get out of this whole blog.

Now onto the big question that lies in this blog post.
Should you use chemo as your Cancer treatment? 


The answer is – THERE IS NO ANSWER! That is the simple truth. No one can say for sure whether you should or should not use it for a certainty. But in this blog post I will share a little about why we ARE using a form of chemotherapy in our treatment protocol.
Initially upon getting a cancer diagnosis we started doing loads and loads of research,
and had absolutely NO DESIRE to do any chemotherapy treatment. We were told that
Filip’s cancer is relatively pretty slow growing, and people can live with it for years. 

That made us think that we had pretty good chances of hitting this thing with all the natural therapies and treatments that we can find! We stumbled upon Chris Wark 
and his whole “Chris Beat Cancer” movement along with several Facebook Groups
like the FenBen Group and the “How to Starve Cancer“, and Hoxsey Group 
where people were getting amazing results and were actually beating cancer! 

Immediately we knew this is the way we wanted to go! 
I highly encourage everyone to be in those group and
read their stories and protocols. 

They are super informative and very encouraging!

However, Filip’s cancer was spreading much faster than expected. Just 2 months after his initial diagnosis his cancer had spread to his spine and a tumor was pressing on his spinal cord resulting in decreased sensation in the lower extremities (legs) and below the waist, and unsteady gait. We realized that his cancer needed to be knocked down so to speak. 

Our Oncologist Dr. Pommier at OHSU recommended we start some serious chemo called Cisplatin and Etoposide along with targeted radiation to the spine to stop the tumor from progressing thereby alleviating the pressure on the spinal cord. Seeing that Filip was not doing well at that time, we agreed and felt that we had no choice and this was our only hope. Maybe it was. But this chemo was way worse than anyone told us.
It almost killed Filip. We were literally sent home with Hospice to die. That was their prognosis after just 1 Chemotherapy treatment and 7 radiation treatments to the spine. Filip spent a total of 2 weeks in the hospital and then was sent home.

Being sent home was exactly what we needed! Hospice provided all the medical
equipment that we needed and being home was the perfect environment for recovery.
After around 2 weeks on Hospice, we fired them, and signed up with Home Health.
Filip kept saying “But I just don’t feel like I am dying!”
Despite being told by the doctors at OHSU (not our oncologist) that he is dying over and over again. I will make a more detailed video documenting our hospitalization experience and why we made the choices that we did.
But this post is about Chemotherapy. The first chemo that Filip got was terrible and not for Filip. (Although I have read multiple accounts of people receiving this same chemo
and almost not feeling bad so this is strictly Filip’s experience). After around 2 month of recovering at home and doing all of our protocols (FenBen, Hoxsey, Valasta, Juicing, etc.) we got a CT scan which showed the tumors had grown. 

It was only a few millimeters of growth but nevertheless it had grown.
(BTW a tumor will grow a little bit when it is dying as a result of all the inflammation
that surrounds it, so that size increase could have been a result of it dying especially
since starting Valasta, but we cannot know for sure). 
Our Oncologist said that Filip is doing well enough to
try a low dose Oral Chemo called CAPTEM.
It is also two different chemo’s consisting of 2 different oral pills
taken for 14 days and then taking 14 days off. He explained that it is much milder
than the previous Chemo and has had great success with Neuroendocrine Cancers.

So, we agreed to try it.

3 months later we had a CT scan which showed amazing results!
View my update video here. To the medical professionals it would seem the CAPTEM is clearly doing its job and killing the cancer! – MAYBE! –
But maybe it’s the Valasta? Or the Juicing? Or the Hoxsey? Or FenBen? 
OR MAYBE IT’S ALL OF IT?!! Again, we just cannot say for sure.
What we can say is that we feel that THESE THINGS WORK!
And therefore, we will continue. 

We absolutely HATE the idea of putting toxic chemo into Filip’s body,
but I have heard of accounts of people on the Hoxsey Group saying they had to
get some chemo to knock down the cancer, and then the herbs take over and do
the rest. We hope that is what is happening in our case. Time will tell.
NATURAL CANCER TREATMENT | Our trip to a clinic in Mexico

Watch: https://youtu.be/MgVIokmgvjQ

🙏 284 views Downloaded Feb 7, 2023

Thank you for watching, please don’t forget to LIKE, COMMENT, AND SUBSCRIBE!
It really helps to spread the word about this amazing place! Read our story here www.mashageorgiev.com Follow us on IG here: @filipandmasha Masha Georgiev | Facebook Watch our adventure channel here: @filipandmasha One of the more popular topics in natural cancer therapy is the Hoxsey Clinic in Tijuana, Baja California 

😎 Hoxsey – The people that Cured Cancer ( Bio-Medical Center – Hoxsey Clinic) | Facebook Also My Blog Post: https://www.solitarius.org/2023/02/27/hoxsey-clinic-qa/

Question:
Hello, questions about hoxsey treatment? When a person goes through the hoxsey treatment, does the person get exhausted/ extreme fatigue? Also, does it affect sleep?
My dad is going through Hoxsey treatment, and he has both the symptoms …please
share if anybody had these symptoms and then felt better after some time.
Thank you so much. 🙂

Comments
Top comments

Brenda Polston Be sure he is drinking lots of water. And put some lemon in it.

Masha Georgiev My hubby is doing Hoxsey and high dose melatonin
not just for sleep but for many other benefits.

Research it but melatonin 10mg generally seems to be ok 👍🏼

Luciana Filippelli McCartney Yes, that is part of the Herx reaction….
he is detoxing. It will improve over time. 

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This is Biden’s Administration

A KGB fled to the U.S. 39 years ago, what he told in the video below
has been continuously confirmed in the U.S.

Watch: a KGB defector’s mid-1980s interview
KGB defector Yuri Bezmenov’s warning to America – YouTube
(If you don’t want to watch the video, the transcript is here.)

Watch this or just listen to a video of Yuri Bezmenov, a KGB defector to Canada, who came to love America and tried to warn Americans about the KGB’s plans. Listening to him is eerie because he spelled out in detail exactly what the Soviet Union was doing — it wasn’t planning to take America down through the military.

Instead, it intended to destroy America from within by infiltrating the education system, three generations of young people to hate this country and each other and then watching them go forth and plant the seeds of self-loathing throughout the nation.

When it came to understanding how the Soviet Union operated, Bezmenov was the
real deal. His father was a high-ranking army officer, so Bezmenov was raised inside the system. He went to KGB schools and worked for the KGB for a decade until he defected to the West, eventually landing in Canada. In the 1980s, Bezmenov was able to move to Los Angeles, where he lived for five years.

It was in L.A., in 1984 or 1985, that he gave an interview to G. Edward Griffin, a conservative writer and thinker. During the interview, Bezmenov explained that the Soviet Union was not interested in fighting America. It was interested, instead, in co-opting it through psychological warfare. It is in that interview that you’ll see above.

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An organized thinker, Bezmenov stated the core principles of his talk in the open minute of the video: But in reality, the main emphasis of the KGB is not in the area of intelligence at all. According to my opinion and the opinion of many defectors of my caliber, only about fifteen percent of time, money and manpower is spent on espionage as such. The other eighty-five percent is a slow process which we call either ideological subversion or active measures, or psychological warfare.

What it basically means is, to change the perception of reality, of every American, to such an extent that despite an abundance of information no one is able to come to sensible conclusions in the interest of defending themselves, their family, their community and their country. It’s a great brainwashing process which goes very slow and is divided into four basic stages. The first one being demoralization.

It takes from fifteen to twenty years to demoralize a nation. Why that many years?
Because this is the minimum number of years required to educate a generation of
students in the country of your enemy, exposed to the ideology of the enemy.

In other words, Marxism, Leninism ideology is being pumped into the soft heads
of at least three generations of American students, without being challenged or
contra-balanced by the basic values of Americanism, American patriotism.
A KGB fled to the U.S. 40 years ago, – Search (bing.com)

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39 years later, Miles Guo, another hero who kept exposing CCP, was arrested by the FBI, DOJ…… Miles Guo not only kept exposing CCP as a trusted information center, but also united all freedom-loving Chinese to destroy CCP. Who are involved in arresting Mr. Guo, as a #1  saboteur of CCP, absolutely like what the KGB said , are helping CCP because of greed or stupidity. All traitors in the US should watch this Video to know how their end, once CCP achieves their goals, The CCP will kill them like cockroaches because they knew too much.

But all of us, ordinary people can only accept to be a slave to be killed and humiliated.
40 years later, Miles Guo, another hero who kept exposing CCP, was arrested by the FBI, DOJ… Miles Guo not only kept exposing the CCP as a trusted information center, but also united all freedom-loving Chinese to destroy the CCP.
Who is involved in arresting Mr. Guo, as a #1 saboteur of CCP, absolutely like what the KGB said, is helping CCP because of greed or stupidity.

Look if those Dems, leftist and radicals wouldn’t be so insistent in FxxKin up Trump’s life.
Knowingly that one of the top Chinese at the lab, informed the regime of the leak. Instead of sending a world alert, they imprisoned the scientist and hushed the virus as long as they could. There’s no question about it. Fauci has GOUT in both hands and probably from drinking alcohol…because committing crimes against humanity and genocide for profits can be a very stressful and guilt-ridden endeavor…

Prince Li: If the Congress really wants to find out the origin of the CCP virus,
I suggest that the U.S. Congress and the U.S. government investigate the relationship between Anthony Fauci and Wang Yanyi, the director general of the Wuhan Institute
of Virology. They have a very intimate relationship!

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0bama gave Wuhan a Grant – Search (bing.com)

Have you noticed several big stores closing down in your city? 
You can thank this smooth-talking Devil for what’s going on in our country, and the world right now. Well, this isn’t just happening around your area but around the whole country.
Several big stores are about to shut down this year, and many want to know why.
Big stores such as Macy’s and J.C.Penny have been struggling ever since the pandemic,
and now that the economy is not looking good, these companies are starting to shut down stores all over the country.
Several big-name stores are now switching to online sales as the internet has taken over everything as everybody started ordering things online due to the pandemic. Some of these big stores have been around forever, so it would be sad to see them go. So if you want to see what big stores are about to shut down this year then stick around.

Turn around is fair play stick the juice to that old decrepit mad scientist.
I think it is HIGH time that F U Fauchi ‘Actually’ be given the Death Jab &
at Least 3 Boosters! I believe in appropriate consequences for your actions!!
He forced this on the World… Now Let Him Be Given the REAL Vax!

(Because we all know he Never took it!)

A video deposition given by Dr. Anthony Fauci has been released publicly.
Video Deposition of Fauci in Gov. Censorship Case Released Publicly | Newsmax.com 

Fauci Lied & Children Died: Secret CDC Documents confirm 120k Children, Teens & Young Adults ‘Died Suddenly’ in the US by Oct. 2022 after
“Emergency” Use Authorization’ of Covid Vaccines – The Expose (expose-news.com)

#Fauci Lied & #Children Died: Secret #CDC 
Documents confirm 120k Children, Teens & Young Adults ‘Died Suddenly’ in the US by Oct. 2022 after ‘“Emergency”
Use Authorization’ of #Covid #Vaccines After that he might have a few months left on this earth, before the Bioweapon He Helped Create takes Him to Meet w/ God & His Eternal Damnation! Pure Justice!

This is all by design. He was The Destroyer.
There’s no justice until this POS is indicted, tried
and sentenced for his crimes against America.

Should have listened when he said he wanted to fundamentally transform America.
I always knew and know this guy is evil to the core with his pure hatred of the US.
His contempt for American blacks was obvious.

I’d go further than that. Damn right !!!
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MOST of our socio-economic-international problems began with this joker.
and his 110 page communist manifesto – Search (bing.com)

“Dilbert Reborn” now exclusively on http://Scottadams.locals.com
(Subscription) with lots more content.

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EXPOSING CORRUPTION & UNITING US on Twitter: “BREAKING: Alvin Bragg’s dog & phony show is another political play straight out of “The Nasty Ass Pelosi Wrap Up Smear Campaign Tactics” 👇🤔 https://t.co/LzVqB29KoY” / Twitter

Steve Bannon’s Warning After Donald Trump’s Indictment (msn.com)
We are watching the Democrat Party Morph into a Fascist-Socialist Regime that feels NO need to explain itself to Americans. Because it was not voted in and won’t be voted in next time. Democrats either don’t believe that people like Adolf Hitler and Joseph Stalin exist today, or they are looking forward to having one in the White House. History is loaded with megalomaniacs… and their followers.

If you knew the crap they do ‘off the books’, black ops, illegal funding from drug running, assassinations, etc… you would be so fuckin scared 🤯 Yup if we only know the tip of the ice burg…  Corrupt Intel Agencies + Corrupt Media + Corrupt Democrat Party = Totalitarian Dystopia. Conspiracy almost always turns out to be fact.

Propaganda opposes alternate views. #WokeMindVirus…c”,)

How much is Joe Biden worth today?

A reported $8 to 9 million…probably Billions laundered away!!!

And these are the people calling Conservatives violent and extremists.

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They have not even begun to scratch the surface of how deep this evil goes…

it’s beyond comprehension… Keep thinking there is an epiphany in our future…

Sad truth The problem is when we start telling people about the truth we get Epsteined!

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Yes, scary truth versus comforting lies 🙈🙉🙊

Enemies within….Absolutely done in overtime!!!
Rome wasn’t destroyed in a day either.

So much miss direction, PSYOP, hidden agendas, down right lies…
The more I spend time on social media, the more I realize I need to spend time
with my Father in Heaven… I think we are to a point that only He can fix this…
What I do here makes little difference…I so agree!!!

Someone gave me a refrigerator magnet as a joke years ago. It says. It is as bad as you think it is. And they are out to get you. My father said to me 20+ years ago, whatever the sickest, craziest, most deplorable thing you can think of-someone, somewhere is doing, they are most likely in government. The man knew.

We know that is why we pray to the force that could help us cope with the evil in this world. Some of us don’t talk about it much because they won’t believe us anyway but we only share it to those who seem serious about it. Full Sean Hannity Interview With President Donald Trump 3/27/2023 – Video – The Last Refuge (theconservativetreehouse.com)

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A federal prosecutor admits three D.C. undercover police officers –
acted as provocateurs on J6.

Marxism vs Communism vs Socialism vs Fascism – Bing video
This is just more evidence that the entire operation was planned, paid for,
instigated and carried out by the US government, FBI, DC Police, and NYC police.
The entire riot was also orchestrated and carried out by government operatives.
Ringleader in Jan6 is Nancy Pelosi. Oh, Nancy Pelosi came out with that saying,
didn’t she? She said, “I have a few more arrows in my quiver.”

Sep 19, 2020, House Speaker Pelosi said that another bogus impeachment is one of the “arrows in our quiver” to block President Trump’s Supreme Court Justice nominee. …more. 
It met she had a few options, in order to accomplish what she wants to accomplish. Literally, a quiver is an arrow bag. She is saying she has more than one trick up her sleeve. Pelosi: ‘We have arrows in our quiver that I’m not about to discuss right now’,    And I believe her. Did you see the look on her face?

Like a cat with a canary in its mouth. 🙀🐦

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Nancy bought. paid for the mas·quer·ade. 

1 a : a social gathering of persons wearing masks and often fantastic costumes b : a costume for wear at such a gathering 2 : an action or appearance that is mere disguise or show masquerade 2 of 2 verb masqueraded; masquerading intransitive verb …This is seriously frightening that a governments and agencies associated to government would do this. Way too much corruption. All to keep power, make money for themselves and control everyone.

Apparently, it shut up Congress for good.
What do they do all day besides NOT ARRESTING @JoeBiden et al?
It feels like they’re waiting for something. Dear Useless Congress:
that #Uniparty thing isn’t taking off now or ever.
Give back your bonuses and get to work A******S
.
We all know what needs to be done.

The DC police are filth along with the FBI, DOJ, CIA, NAS, ATF you name the government agency, and you see political corruption. They wanted no opposition to a fixed election. Has the FBI been cleaned up?
 NO…Will it happen again…. YES!!!

We are the one going to question.
Of those people, why they RiGGED the election , and the evidence they made it go away.

Why are they so corrupted?

They put whatever they want, not the people’s choices first.
They are so evil and corrupted.

We need those people to Resigned…NOW!!!

That’s a lot of feds who interfered in the election process. They need to be dealt with swiftly and severely. Planned by Pelosi & Schumer with assistance from democratic congress Representatives & Senators. As a concerned citizen I really want to know, how does this work?
Your higher up puts out an email asking for volunteers to instigate people at the capitol building to try to cause a riot or an insurrection?

How does this even come to be??

The Last Days According to Jesus, Revised and Updated Edition: 
When Did Jesus Say He Would Return?:  Christianbook.com

“I am.” Hey , gotta’ be me.
I don’t know how to be anyone else.
If you don’t like my opinions,
I’m sorry they are the only ones I got.

*•.¸♡ 𝘓𝘪𝘬𝘦𝘥 & 𝘙𝘦𝘛𝘸𝘦𝘦𝘵𝘦𝘥 ♡¸.•*
✿。:✿。:*𝙿𝚕𝚎𝚊𝚜𝚎 𝙵𝚘𝚕𝚕𝚘𝚠*:。✿
╰☆ GOD BLESS AMERICA ☆╮
»★« #Patriots Assemble »★«
╰☆☆ #𝐕𝐞𝐭𝐭𝐞𝐝𝐏𝐚𝐭𝐫𝐢𝐨𝐭𝐬 ☆☆╮

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Fasting for Gut Repair

Should You Tell Your Boss You Have IBD?
Plus, More Tips for Coping at the Office
BY ELIZABETH MILLARD


As the human resources director for Family Destinations Guide, a website that offers kid-friendly vacation ideas, Bonnie Whitfield always makes sure employees feel comfortable disclosing their medical conditions so the company can provide accommodations. For Whitfield, it’s not just professional—it’s personal, because she has inflammatory bowel disease (IBD).

“Since I have IBD myself, and I’ve been through a few flare-ups at work,
I know what it’s like to be in that situation,” she says. Employees are often trying to navigate not just the symptoms of a chronic illness, but also anxiety over questions like: Should I tell my employer and coworkers? Will people feel like they can’t count on me? What if I’m embarrassed to talk about it?

These are all common concerns, says Whitfield, and unfortunately, worrying about such issues can actually put you at higher risk for an IBD flare that could affect your work.

IBD encompasses two conditions—Crohn’s disease and ulcerative colitis—that are characterized by inflammation of the gastrointestinal tract, leading to symptoms like diarrhea, abdominal cramping, fatigue, and sudden weight loss. Treatment options help many people go into remission so their condition becomes a non-issue, but even on medication, symptoms may return in a flare-up that can range from mild to debilitating and might last days or weeks. The unpredictability of the disease is another source of potential anxiety when considering how it will affect work performance, Whitfield says.

“Sometimes, pushing yourself can make your flare worse,” she adds. “Having a plan in place beforehand can go a long way toward keeping you productive while still taking care of yourself. It’s important to remember that being sick shouldn’t mean you can’t be an effective employee.” Here are some tips to consider when balancing your health and your workplace, even if your IBD is in remission right now.

Let your employer know—and put it in writing.
Although the symptoms of IBD—like frequent trips to the bathroom, gassiness,
and bloating—can feel embarrassing, it’s important to recognize you have a
chronic illness and that it should be handled as such, Whitfield advises.

She suggests telling your direct supervisor and HR director not just about your condition, but also what you need in terms of accommodation and why that will help you function better in the workplace. For example, many people with IBD benefit from having an office or cubicle closer to the bathroom, which can shorten the amount of time spent going back and forth during a flare.

Also, simply being closer might reduce worry about the issue, and in itself that could
tamp down some symptoms. Having to use a wheelchair may also come into play, since side effects used to treat ulcerative colitis can lead to mobility challenges, so letting an employer know that could be a possibility—and ensuring you have access to all the areas you need—is crucial for planning ahead.

There may be multiple doctor visits as well, especially when flares are more dominant, and treatment could include options like surgery in the future. Preparing an employer for that possibility should be part of the conversation about your condition.

Whitfield says putting information like this into writing is the best approach, since it provides the most clarity about what you need. Plus, it ensures that all parties are receiving the same information. “Explain how IBD affects your work performance and how you can still do your job effectively while keeping up with treatment regimens and any other responsibilities required by the company, such as working overtime,” she adds.

“The more specific you can be about what accommodations would help keep you healthy and productive, the better equipped your employer will be to develop a plan that works for both of you.” Another benefit to writing it down: It may feel easier than saying everything in a meeting, particularly with multiple people or those you don’t know well.

For instance, when Los Angeles-based Span Chen was working as a cashier, every day felt like a battle due to pain and the inability to leave a line of customers. Treatment helped reduce flare-ups, but also led to more fatigue. He felt hesitant to bring up his struggles.

“What helped was writing a letter to my boss explaining what was going on, and that
I needed to take time off in order to heal fully,” says Chen. “Because I wrote it down,
I didn’t forget key points, like saying that being able to have more time away from
work would allow me to return to full health.”

Read More: How to Maintain Your Social Life When You Have IBD

Establishing some code words and contingency plans.
Even just having a key phrase can be useful, says Cassie Mahon, who leads client
meetings for her employer in Columbia, Missouri. She informed her boss about her IBD &
together they formulated a plan of action about what to do if Mahon had to leave suddenly.

“If I say that it’s time for a short break, she understands what’s going on and
we don’t have to tell everyone else in the room what’s happening,” she says,
adding that sometimes her boss will step in to continue a presentation if necessary.
That might seem like a minor tweak to the process, but Mahon says it provides much-needed reassurance that her work can continue with minimal disruption.

Stick to your routine.
Although IBD might not be predictable, your work schedule still can be, if you have the option of being flexible about location. That means making sure you’re able to work from home occasionally and that there’s a plan in place for those days, including having a home office setup and access to online company resources.

“Stay true to your usual routine as much as possible, which can help take some of the stress out of an IBD flare,” Whitfield says. “This can keep your life feeling normal while also giving your body time to recover.” Of course, not everyone has the option of working from home, but if it’s a possibility for you and can alleviate some of the worry around being in the office, it’s helpful to incorporate at-home time when you can.

If it’s not possible, Whitfield says that creating a more flexible work schedule could be another beneficial strategy. For instance, if being around so many coworkers makes you anxious about flares, you might swap one weekday for working on a weekend day so you’re in the office with fewer people.

Keep supplies on hand.
Another part of preparation is knowing what you need so you have items at the ready,
no matter what. For Boston-based Keyla Caba, being anywhere that’s not home can be difficult with her IBD, particularly because she wears an ileostomy pouch—a special bag that collects waste from the colon—which must be emptied regularly.
After years of fretting over the distance between her desk and restroom, she decided to make it a priority to make her experience more comfortable and address her fears about not making it to the bathroom in time.

That has meant always having spare clothes at the office, as well as some sort of deodorizing spray, and a sign she would hang on her desk to let colleagues know
she was having a flare and needed extra time away.

“This was the start of how I transformed the office bathroom into a peaceful experience
for myself, and relieved my restroom anxiety,” Caba says. “Knowing I have what I need
on hand can reduce my fears about flares.”

Know your rights.
Even if company management and HR are happy to accommodate your needs
as someone with IBD, it’s still essential to know your rights as an employee, says
Kia Roberts, principal and founder of Brooklyn, New York-based Triangle Investigations, which handles assessments of workplace misconduct. For example, she recently worked on a harassment case for a person with Crohn’s disease who wasn’t given accommodations by her manager.

“Most workplaces today understand the importance of not discriminating against employees based on protected characteristics like race, sexuality, gender, and ethnicity, but many employers do not understand the importance of having a policy on how employees with health issues should be treated within the workplace,” says Roberts.
“If an employee feels they are being singled out for different treatment based on their health issues, that could represent discrimination on the part of the employer.”

Another important aspect of your rights: If your IBD is disabled, it’s protected under the Americans with Disabilities Act, which means your employer must make reasonable accommodations. You may also be covered under the Family and Medical Leave Act, which entitles eligible employees to take unpaid, job-protected leave for medical reasons—up to 12 weeks of leave within a 12-month time period.

Focus on gut-healthy lifestyle habits.
Part of being more productive at work comes from what you do outside of the office, and that means implementing the right lifestyle behaviors, according to Dr. Ashkan Farhadi,
a gastroenterologist at MemorialCare Orange Coast Medical Center in Fountain Valley, Calif. In addition to making sure you follow treatment protocols like medication you may be prescribed, you can lower risk of flares by focusing on gut health, he says.

“Diet will, of course, play a major role in your IBD management, but equally important are other habits that improve your gut microbiome,” Farhadi says. “The three most prominent are sleep, stress reduction, and exercise, because if you get those on track along with your diet, it can significantly reduce the frequency and severity of flares.”

For example, there’s a strong association between sleep difficulties and gut function, which can lead to more than just daytime sleepiness or flares at work. A 2018 study in the journal Frontiers in Psychiatry found that insomnia has been linked to poor immune function, difficulty absorbing certain nutrients, and depression.

Read More: These Environmental Factors Increase the Risk of IBD

Staying aware of potential overwhelm.
Stress is another big challenge when it comes to avoiding flares,
adds Dr. Rudolph Bedford, a gastroenterologist at Providence Saint John’s
Health Center in Santa Monica, Calif.

“Chronic stress has a ripple effect on your gut microbiome, which means it can impair your gastrointestinal system and keep it from functioning well,” he says. “When you have IBD, that means it could make your flares more intense, or could cause flares even if they’ve been well managed in the past.”

A significant part of better stress control comes from evaluating all aspects of your everyday activity, and that includes work. If you’re feeling frazzled, that’s another conversation to start with your supervisor and HR.
“When someone has a chronic illness like IBD, remember that it should be a team effort
in terms of management,” Whitfield says. “The more that people around you understand
what’s going on, the more it will benefit you, your company, and your coworkers.”

Your gut is endangered. And that’s not a good thing for your health—or the health of the rest of the world.
Your gut is endangered. And that’s not a good thing for your health—
or the health of the rest of the world. © Getty Images

The Human Microbiome Is Going Extinct, Scientists Say.
The End Will Be Devastating. Story by Tim Newcomb.

Researchers say the human microbiome that lives in your gut is now endangered.
The loss of bacteria and microorganisms reduces your chance at a healthy life.
You’re the one killing off your own microbiome. The human microbiome is endangered.
And that’s not a good thing for your health—or the health of the rest of the world.

A new documentary, The Invisible Extinction, highlights how the human microbiome—also known as the bacteria and microorganisms living within the human body, most prevalent in the gut—is on the verge of extinct. And it’s all your fault.

The Invisible Extinction Movie: The Quest to Save the Microbiome!

There’s a war raging in our bodies, and the casualties are the bacteria that live in our gut. These bacteria, known as the microbiome, are crucial for our health, but factors like antibiotics, C-sections, and processed foods are threatening their survival. In the new documentary film “The Invisible Extinction,” doctors Martin Blaser and Gloria Dominguez-Bello embark on a mission to save the microbiome.
These tiny organisms help us digest food, make vitamins, and protect us from illness. They can be found all over the body, but most reside in the gut. People with a more diverse microbiome tend to be healthier. Researchers have used poop (yes, you read that right!) to study the microbiome and its connection to diseases like inflammatory bowel disease, multiple sclerosis, liver disease, diabetes, and autism.
Antibiotics can be harmful to the microbiome because they can kill off both good and bad bacteria. To keep our microbiomes happy and healthy, it’s important to eat a varied diet, avoid unnecessary antibiotics, and consider vaginal delivery over C-sections.

In a discussion with People, two researchers behind the doc, Martin Glaser and Gloria Dominguez-Bello, say the human microbiome is essential for us to digest food, make vitamins, and train our immune systems. “When we eat,” Blaser tells People, “we are nourishing both our human cells and also our microbial cells.”

The slow death of the human microbiome is thanks to our modern way of life. We use antibiotics to kill off bad bacteria. But antibiotics kill off plenty of the good stuff, too. Blaser says the more antibiotics given to a child, the more likely they are to develop a range of illnesses. Blaser adds that the Centers for Disease Control and Prevention
(CDC) estimates about one-third of antibiotic prescriptions are unnecessary,
leading to the overuse.
Then there’s the highly processed, chemical-laden food that’s wreaking havoc on our gut health. “The single most important component of the diet to feed the microbiome is fiber,” Dominguez-Bello says. These fibers feed your microbiome, while processed food removes the fiber, posing a negative result for your microbiome.

The researchers want better options for the antibiotic issue, both with improved testing to see if a bacterial infection is really in play, and by developing new antibiotics that don’t have the “collateral damage that is killing every bacterium inside.”
“We are making a complete mess of biodiversity, including microbes,” Dominguez-Bello says. “Microbes are essential in every ecosystem, not only in humans or animals or plants, but also in the oceans. The whole thing is linked together by the impact of human activities. We need to preserve microbes because they really modulate functions of Earth. They modulate the climate. They modulate everything. They modulate our own gene expression.”

The human microbiome is a big deal. Let’s not kill it.
https://www.theinvisibleextinction.com/

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How Fasting Can—and Can’t—Improve Gut Health
BY MARKHAM HEID 


What is fasting and how does it work. – Bing video
If you spend a lot of time online, you may have noticed that parts of the internet have caught fasting fever. Online message boards are awash in posts touting the benefits of time-restricted eating and other intermittent-fasting approaches that involve going without caloric foods or drinks for an extended period of time—anywhere from 12 hrs.
to several days.

These online testimonials have helped popularize intermittent fasting, and they
often feature two common-sense rationalizations: One, that human beings evolved in environments where food was scarce and meals occurred sporadically; and two, that the relatively recent shift to near round-the-clock eating has been disastrous for our intestinal and metabolic health.

Mining the internet for accurate information, especially when it comes to dieting, can feel like panning for gold. You’ve got to sift through a lot of junk to find anything valuable. But this is one case where nuggets may be easy to find. A lot of the published peer-reviewed research on intermittent fasting makes the same claims you’ll find on those Reddit message boards.

“Until recently, food availability has been unpredictable for humans,” wrote the authors of a 2021 review paper in the American Journal of Physiology. “Knowledge of early human evolution and data from recent studies of hunter-gatherer societies suggest humans evolved in environments with intermittent periods of food scarcity.”
They say that fasting regimens may provide a period of “gut rest” that could lead to several meaningful health benefits, including improved gut microbe diversity, gut barrier function, and immune function. 

The past decade has witnessed an explosion in fasting-relatedid research. (According to Google Scholar, the last five years alone contain almost 150,000 articles that examine or mention fasting.) While that work has helped establish links between intermittent fasting and weight loss, as well as other benefits, it’s not yet clear when (or if) fasting can help fix a sick gut.

“I would still consider the evidence moderate,” says Dr. Emeran Mayer, a professor of medicine and founding director of the Goodman Luskin Microbiome Center at the University of California, Los Angeles. “[Fasting] looks like a prudent way to maintain metabolic health or reestablish metabolic health, but it’s not a miracle cure.

When it comes to gut conditions such as inflammatory bowel disease (IBD),
he says the research is either absent or inconclusive.
To his point, researchers have found that Ramadan fasting—a month-long religious period when people don’t eat or drink between sunrise and sunset—can substantially “remodel” the gut’s bacteria communities in helpful and healthy ways. However, among people with IBD, studies on Ramadan fasting have also found that a person’s gut symptoms may grow worse.

While it’s too early to tout fasting plans as a panacea for gut-related disorders, experts say there’s still reason to hope these approaches may emerge as a form of treatment. It’s clear that some radical, and perhaps radically beneficial, things happen when you give your body breaks from food.

How fasting could repair the gut.
For a series of recent studies, a team of researchers based in the Netherlands and China examined the effects of Ramadan-style intermittent fasting on the gut microbiome—the billions of bacteria that reside in the human gastrointestinal tract. (Ramadan comes up a lot in published research because it provides a real-world opportunity for experts to examine the effects of 12- or 16-hour fasts, which is what many popular intermittent fasting diets espouse.) 

“We really wanted to know what intermittent fasting does to the body,” says Dr. Maikel Peppelenbosch, a member of that research team and a professor of gastroenterology at Erasmus University Medical Center in the Netherlands. “Generally, we’ve seen that intermittent fasting changes the microbiome very clearly, and we view some of the changes as beneficial. If you look at fasting in general, not only Ramadan, you see certain types of bacteria increasing.”

When Butyrate Levels are high cancer risk is low.
For example, he says that intermittent fasting pumps up the gut’s population of a family
of bacteria called Lachnospiraceae. “In the intestines, bacteria are constantly battling for ecological space,” he explains.
Unlike some other gut microorganisms, Lachnospiraceae can survive happily in an empty GI tract. “They can live off the slime the gut makes itself, so they can outcompete other bacteria in a fasting state.” 
Lachnospiraceae produces a short-chain fatty acid called butyrate, which seems to be critically important for gut health. Butyrate sends anti-inflammatory signals to the immune system, which could help reduce pain and other symptoms of gut dysfunction. 

Butyrate also improves the barrier function of the intestines,
Peppelenbosch says. This is, potentially, a very big deal.
Poor barrier function (sometimes referred to as “leaky gut”) is a hallmark of common
G.I. conditions, including inflammatory bowel disease. If intermittent fasting can turn down inflammation and also help normalize the walls of the GI tract, those changes may have major therapeutic implications.

Lachnospiraceae is only one of several types of helpful bacteria that research has linked to fasting plans. But at this point, there are still a lot of gaps in the science. Peppelenbosch says the guts of people with bowel disorders don’t seem to respond to fasting in exactly the same way as the guts of people without these health issues. “In ill people, we see the same changes to the microbiome, but it’s not as clear cut as in healthy volunteers,” he says. “So we are now actually trying to figure out what’s going on there.

”Healthy microbiome shifts aren’t the only possible benefits that researchers have linked to intermittent fasting. UCLA’s Mayer mentions a phenomenon called the migrating motor complex. “This is rarely mentioned in fasting articles today, but when I was a junior faculty it was one of the hottest discoveries in gastroenterology research,” he says. The migrating motor complex refers to recurrent cycles of powerful contractions that sweep the contents of the gut, including its bacteria, down into the colon.

“It’s this 90-minute recurring contractile wave that swoops down the intestine, and its strength is comparable to a nutcracker,” he says. Essentially, this motor complex behaves like a street-cleaning crew tidying up after a parade. It ensures the gut is cleared out and cleaned up in between meals, via 90-minute repeating cycles that fasting allows to become more frequent. It also helps rebalance the gut’s microbial populations so that more of them are residing in the colon and lower regions of the GI tract. “But it’s stopped the minute you take a bite—it turns off immediately,” he says.

Mayer says that modern eating habits—so-called “grazing,” or eating steadily throughout the day—leave little time for the migrating motor complex to do its thing. “This function has been relegated to the time when we sleep, but even this has been disrupted because a lot of people wake up in the middle of the night and snack on something,” he says. “So those longer periods of time when we’re-cleanse and rebalance our gut so that we have normal distributions of bacteria and normal population densities—that has been severely disturbed by these lifestyle changes.

”Ideally, Mayer says people could (for the most part) adhere to the kind of time-restricted eating program that allows a full 12-to-14 hours each day for the motor complex to work. “If you don’t snack, this motor complex would happen between meals, and you’d also get this 12- to 14-hour window at night where the digestive system was empty,” he explains.
In other words, sticking to three meals a day and avoiding between-meal bites (or nighttime snacks) could be sufficient. But again, it’s not clear whether this sort of eating schedule can undo gut damage or treat existing dysfunction.

Read More: The Truth About Fasting and Type 2 Diabetes

More potential benefits.
Another possible perk of fasting involves a biological process called “autophagy.”
During autophagy, old or damaged cells die and are cleared away by the body.
Some researchers have called it a helpful housekeeping mechanism, it occurs
naturally when the body goes without energy (calories) for an extended
period of time.

There’s been some expert speculation, based mostly on evidence in lab and animal studies, that autophagy could help strengthen the gut or counteract the types of barrier problems seen in people with IBD. But these improvements have not yet been demonstrated in real-world clinical trials involving people.

Meanwhile, some experts have found that fasting may help recalibrate the gut’s metabolic rhythms in helpful ways. “By changing the timing of the diet, this will indeed change activity of the microbiome, and that may have downstream impacts on health,”
says Dr. Eran Elinav, principal investigator of the Host-Microbiome Interaction Research Group at the Weizmann Institute of Science in Israel.

Some of Elinav’s work, including an influential 2016 paper in the journal Cell, has shown that the gut microbiome undergoes day-night shifts that are influenced by a person’s eating schedule, and that lead to changing patterns of metabolite production, gene expression, and other significant elements of gut health. “If you change the timing of diet, you can flip the circadian activity of the microbiome,” he says. This is likely to have health implications, though what those are, precisely, remains murky.

Read More: What We Know About Leaky Gut Syndrome

Fasting isn’t going anywhere.

It’s clear that when you eat, including how often you eat, matters to the health of your gut. But the devil’s in the details. At this point, it’s not clear how intermittent fasting can be used to help people with gut-related disorders or metabolic diseases.

“For a condition like IBD, it’s important to differentiate between what you do during a flare and what you do to prevent the next flare,” Mayer points out. The research on people observing Ramadan suggests that, at least during a flare, fasting may make a person’s IBD symptoms worse. Figuring out whether fasting could also lead to longer-term improvements is just one of many questions that needs to be answered.

While plenty of unknowns remain, experts say that common approaches to fasting appear to be safe for most people. Time-restricted eating, for example, involves cramming all your day’s calories into a single six-to-eight-hour eating window. Even among people with metabolic diseases such as Type 2 diabetes, research suggests that this form of fasting is safe, provided a person is not taking blood-glucose medications.

That said, there simply isn’t much work on intermittent fasting as a treatment
for gut problems. Also, there is very little research on more extreme forms of fasting,
such as plans that involve going without calories for several days at a stretch.

These diets may turn out to be therapeutic, but they could also turn out to be dangerous.
If you’re considering any of these approaches, talk with your health care provider first.

“We really need much better studies to compare all the different fasting protocols,”
says Peppelenbosch. “But generally speaking, increasing the space between calorie consumption is a good thing for you. The body is not made to be eaten all day.”

Top Doctor: If You Eat Oatmeal Every Day, This Is What Happens BY GUNDRY MD – Search (bing.com)
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