The Metabolic Syndrome

   When you think metabolism ….you have to think everybody’s is either slow/fast, acidic or aklaline  at least I do.  In order to keep it  functioning properly you have to stay active and  consume proper nutrition  (you are proverbially what you eat.)  If  you have a slow metabolism…. your body might produce more cholesterol,  thereby,  making you have to  rev  your body up…. by  doing  vigorous  exercise…. to  burn off  the excess amount      (I began at fifty doing cardio riding a mountain bicycle religiously.)

   While  it’s important  to  keep  your  pH Balance  in check  because  it controls protein structures,  potassium  and calcium concentrations  for  overall nutrient metabolism  (carbohydrates  are primarily catabolized      for energy,  however,  small amounts are anabolized  by  glycogenesis.) With protein being vital  as  well,  because  when  you  don’t  get  proper amounts your body can go into three different disorders:  MARASMUS:           is characterized by tissues wasting and fluid imbalances of electrolytes, KWASHIORKOR:  caused  when  your  body  lacks  proper protein  with sufficient calories.

   With the third state being much like cachexia which a cancer patient        goes  through. The metabolic syndrome x:  is a combination of  medical  disorders that when occurring together increase the risk  for developing  cardiovascular disease, cancer  and  diabetes.  Most  patients  are older,  obese with sedentary lifestyle  and having a degree of insulin resistance.  The pathophysiology regarding whether insulin resistance, obesity and  stress is often misunderstood.

    It is common  for there  to  be  a development  of  central visceral  fat,    after which  adipocytes  ( fat cells)  of  the verceral  fat  increases plasma levels of  tumor necrosis  factor – alpha (TNF-a)  while altering a number      of  other substances (e.g. adiponectin, resistin and PAI-1. TNF-a has been  shown, not only, to cause the production of inflammatory cytokines, but also, possibly trigger cell signaling by interaction with a TNF-a receptor that may lead to insulin resistance  (Lavalle Metabolic Institute.)

   If they’re consequences of  a  more  far reaching derangement occurs.          A number  of  systemic inflammation,  including  C-reactive protein  are  often increased as are  fibrinogen,  interleukin 6  amongst others.  Some have pointed to a  variety of causes, including increased uric acid levels caused  by  dietary  fructose.  This  fructose will  first elevate blood level  triglycerides which induce visceral fat and ultimately results in insulin resistance.

    This  progression  from visceral  fat often increases  TNF-a  to insulin resistance has  parallels to human development  of  metabolic syndrome. The increase in adipose tissue also increases the number of immune cells present within,  which plays an important role in chronic inflammation. Chronic inflammation  contributes  to  an  increase risk of  hypertension, arthersclerosis, cancer and diabetes.

   Recent research, also indicates prolonged stress upsets the hormonal balance  of  the  hypothalamic  pituary  adrenal – axis (HPA-axis.)  and  a dysfunction here causes high cortisol levels to circulate,  which  in  affect causes raising glucose  and  insulin levels.  Which in turns causes insulin medicated effects  on adiopose tissue,  ultimately promoting visceral  fat adiposity, insulin resistance, dyshipidemia and hypertension.

    Central obesity is a key  feature of  the syndrome,  however,  despite          the importance of  obesity.  People of  normal weight can also be insulin resistant and have the syndrome. Therefore, those whom are physically inactive  or lead sedentary lifestyles…. are more prone  to  reduced  HDL cholesterol  and  a trend toward increased triglycerides, blood pressure,  and glucose in the genetically susceptible.


https://www.youtube.com/watch?v=Xm6YuIsROSM

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