When you think metabolism ….you have to think everybody’s is either slow/fast, acidic or aklaline at least I do. In order to keep it functioning properly you have to stay active and consume proper nutrition (you are proverbially what you eat.) If you have a slow metabolism…. your body might produce more cholesterol, thereby, making you have to rev your body up…. by doing vigorous exercise…. to burn off the excess amount (I began at fifty doing cardio riding a mountain bicycle religiously.)
While it’s important to keep your pH Balance in check because it controls protein structures, potassium and calcium concentrations for overall nutrient metabolism (carbohydrates are primarily catabolized for energy, however, small amounts are anabolized by glycogenesis.) With protein being vital as well, because when you don’t get proper amounts your body can go into three different disorders: MARASMUS: is characterized by tissues wasting and fluid imbalances of electrolytes, KWASHIORKOR: caused when your body lacks proper protein with sufficient calories.
With the third state being much like cachexia which a cancer patient goes through. The metabolic syndrome x: is a combination of medical disorders that when occurring together increase the risk for developing cardiovascular disease, cancer and diabetes. Most patients are older, obese with sedentary lifestyle and having a degree of insulin resistance. The pathophysiology regarding whether insulin resistance, obesity and stress is often misunderstood.
It is common for there to be a development of central visceral fat, after which adipocytes ( fat cells) of the verceral fat increases plasma levels of tumor necrosis factor – alpha (TNF-a) while altering a number of other substances (e.g. adiponectin, resistin and PAI-1. TNF-a has been shown, not only, to cause the production of inflammatory cytokines, but also, possibly trigger cell signaling by interaction with a TNF-a receptor that may lead to insulin resistance (Lavalle Metabolic Institute.)
If they’re consequences of a more far reaching derangement occurs. A number of systemic inflammation, including C-reactive protein are often increased as are fibrinogen, interleukin 6 amongst others. Some have pointed to a variety of causes, including increased uric acid levels caused by dietary fructose. This fructose will first elevate blood level triglycerides which induce visceral fat and ultimately results in insulin resistance.
This progression from visceral fat often increases TNF-a to insulin resistance has parallels to human development of metabolic syndrome. The increase in adipose tissue also increases the number of immune cells present within, which plays an important role in chronic inflammation. Chronic inflammation contributes to an increase risk of hypertension, arthersclerosis, cancer and diabetes.
Recent research, also indicates prolonged stress upsets the hormonal balance of the hypothalamic pituary adrenal – axis (HPA-axis.) and a dysfunction here causes high cortisol levels to circulate, which in affect causes raising glucose and insulin levels. Which in turns causes insulin medicated effects on adiopose tissue, ultimately promoting visceral fat adiposity, insulin resistance, dyshipidemia and hypertension.
Central obesity is a key feature of the syndrome, however, despite the importance of obesity. People of normal weight can also be insulin resistant and have the syndrome. Therefore, those whom are physically inactive or lead sedentary lifestyles…. are more prone to reduced HDL cholesterol and a trend toward increased triglycerides, blood pressure, and glucose in the genetically susceptible.