Putting The Brakes 0n Cancer

   Cancer is the alteration of  DNA  signaling and out of  control growth,           altered   DNA  caused  by  tobacco  usage,  alcohol  abuse,  radiation  and     radon exposure, ultra violent rays from sunshine and exposure to toxins  like aflatoxin  and other carcinogens.  However,  with that said in nearly        all cancers,  the  p53 gene  is either damaged  or missing  which  leads to   the growth of  cancerous cells;  and with p53 playing a vital role in cells,     it  is  presentable  in  nearly  all  cancer  types   found  in  human  beings. http://www.ted.com/jay_bradner_open_source_cancer_researchhttp://www.news-medical.net/health/What-is-DNA.aspx

     Along  with  other  proteins,  essentially  monitors  the  health  of  cells, cellular DNA and when irregularity is sensed,  p53 aid in deciding whether to repair  or  begins apoptosis.  As  a transcription  factor,  p53  initiates the transcription of  a group  of  targeted  genes.  One of  the most important of  these  genes  is  p21.  The  product of  p21  is a negative regulator  of  cyclin – depended kinases,  enzymes that deal with the progression of  the cell cycle and cell division.    http://media.hhmi.org/hl/03Lect1.html

   The transcription of  p21, thereby, ultimately prevents all proliferation. Because of  this, the cells are given the opportunity repair damages; and if this  damage  is irrepairable  and  there is significant alterations,  p53 will trigger apoptosis and prevent the damage cell  from responding.  It is also important to note, however, that a cell lacking p53 does not automatically lead to cancerous cells;  though it certainly increases  the likelihood  for a    cell  to  be  cancerous cancer.

  Thereby, a dysfunctional  p53 would lead to the accumulation and such mutations and damages. Mutations can occur in regulatory regions in the p53 gene  that  can  lead  to  a number of  consequences,  depending  on  the extent and location of alterations. These areas regulate gene transcription in a region called, “the promoter area”  which can result in the lack of  p53 as  we  start  figuring  out  what  makes  cancer  tick.  

   Mutations can also occur in the protein coding region of the gene which would then alter the activity of  the protein. There  would  be  a  decrease in  the role  p53  as a transcription  factor.  Hence,  a mutation  in the p53 gene  can  lead  to  LI – Fraumeni Syndrome;  which  occurs  when  an  off – spring  receives a defective copy of  the p53 gene.  This often leads  to various types of  cancers, including breast and thyroid cancers at very young ages.

  Studies have shown that p53 drug therapy is one very effective treatment for cancer,   which  p53  is  administered  in  the  form  of  the  drug  Advexin. Advexin,  injects  p53  protein, in high concentrations into cancer tissue that cancer cells  are  selectively  destroyed  and  the  surrounding  cells  remains unharmed.   Allowing  The Cancer Patient  to Becoming  A  Cancer  Survivor Through  Cancer  Survivorship.    Dr.  Wafik  S.  El-Diery+video&tbm=vid search_query=how+does+the+p53+gene+become+damaged&sm=1

http://www.sharecare.com/health/cancer-prevention/immune-system-fighting-cancer

http://www.sharecare.com/health/cancer-prevention/vitamin-d-decrease-cancer-risk

World_Health_Organization_cancer_risk_Western_medicine

http://www.youtube.com/watch?v=k1hmoo3lnTo

http://www.youtube.com/search query=healthy+cell+pack+full+video

http://www.youtube.com/watch?v=Ao9cVhwPg84

http://www.youtube.com/watch?v=4cpzrcp5M7Q

http://www.youtube.com/watch?v=zwibgNGe4aY

http://www.youtube.com/watch?v=1CUDldQsmmQ

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